Scientific Research - Combating Weapons of Mass Destruction


To support and stimulate basic, applied and advanced research at educational or research institutions, non-profit organizations, and commercial firms, which support the advancement of fundamental knowledge and understanding of the sciences with an emphasis on exploring new and innovative research for combating or countering Weapons of Mass Destruction (WMD).

General information about this opportunity
Last Known Status
Program Number
Federal Agency/Office
Defense Threat Reduction Agency (Dtra), Department of Defense
Type(s) of Assistance Offered
B - Project Grants
Program Accomplishments
Fiscal Year 2019 Awarded grants for basic research in areas such as Bifunctional Materials for CWA Defeat: Integrating Catalysts in High Capacity Mesoporous Metal Oxide Absorbents; De novo computational design of catalytic peptide and peptoid macrocycles; and Enhanced Diffusion of Chemical Warfare Agents in Metal-Organic Frameworks for Detoxification.
Fiscal Year 2023 Awarded several new grants in the area of chemical and biological, cooperative threat reduction, and other mission related basic research. One such award to the University of Wisconsin for neutralizing bacterial bioweapons in the human gut through precision microbiome editing.
10 U.S.C. 2358 (R&D Grants and cooperative agreements). 10 U.S.C. 2361 (Grants & contracts to universities-competitive). 10 U.S.C. 2371 (Transactions other than contracts and grants).
Who is eligible to apply/benefit from this assistance?
Applicant Eligibility
As stated in individual program BAAs. Generally, competitions are open to private and public educational accredited institutions of higher education that carry out science and engineering research and/or related science and engineering education on a non-profit basis. Some awards are made to other non-profit and for profit organizations that conduct research. Awards are not made to individuals.
Beneficiary Eligibility
See above.
Award is subject to: 1) receipt of applicable/acceptable certifications and representations; 2) having a current registration in the System for Award Management (SAM) (; 3), the applicant, its principals, proposed subrecipients/subrecipient principals not appearing in SAM Exclusions as currently debarred, suspended, or otherwise ineligible; and 4) meeting other requirements specified in the agency announcements.
What is the process for applying and being award this assistance?
Pre-Application Procedure
Preapplication coordination is not applicable.
Application Procedure
2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. Eligible applicants may submit white papers or proposals in response to relevant Broad Agency Announcements (BAA) published on or under "Other Defense Agencies - DTRA". Each BAA identifies to potential applicants and what activities or research topic areas will be supported, and how to apply.
Award Procedure
Award decisions are based on evaluations of proposals using peer and/or scientific review. Evaluation criteria are contained in the relevant BAA. If selected for award, the proposal is the basis for the award document and the applicant agrees to perform the research or research related activities described therein.
Review the appropriate funding announcement for due date and deadline information.
Approval/Disapproval Decision Time
Award times will be identified in the relevant BAA. Typically, decisions are made within 90-120 days of receipt of proposal for which funding is authorized.
Not applicable.
Re-application with new proposals is permitted.
How are proposals selected?
Generally, the principal evaluation and selection criteria are the technical or socio-economic merits of the proposal and potential long term contributions of DTRA's specific mission. Other selection criteria vary with the nature of the specific research or research-related activity. Typically, these include the qualifications, capabilities, and experience of the proposed Principal Investigator and/or key personnel who are critical in achieving the proposal objectives; adequacy of current or planned facilities, and equipment; and reasonableness and realism of the proposed costs.
How may assistance be used?
Uses and restrictions are specified in individual program BAAs and award documents issued by and codified regulations applicable to awards. These are submitted at the time of proposal or prior to award, as specified by executive agents.
What are the requirements after being awarded this opportunity?
Not applicable.
Audit requirements for for-profit organizations, which are not subject to 2 CFR part 200, are consistent with the requirements in the DoD Grant and Agreement Regulations (DoDGARs) at 32 CFR 34.16.
Record keeping requirements are in accordance with the terms and conditions of the award, which will include appropriate provisions related to recipient records that are required by the DoDGARs.
Other Assistance Considerations
Formula and Matching Requirements
Statutory formula is not applicable to this assistance listing.

Matching requirements are not applicable to this assistance listing.

MOE requirements are not applicable to this assistance listing.
Length and Time Phasing of Assistance
Since this is a research and technology program, the assistance is generally for the period of performance as stated in the individual grant, agreement or TIA. Funding is usually provided incrementally in accordance with a payment schedule contained in the award document. Grants are normally a base period and option years up to five total years. Assistance might be released fully funded or incrementally.
Who do I contact about this opportunity?
Regional or Local Office
None/Not specified.
Headquarters Office
Mary Kay Chase
8725 John J. Kingman Road
Fort Belvoir, VA 22060 US
Phone: 571-616-6159
Website Address
Financial Information
Account Identification
(Project Grants) FY 22$77,510,287.00; FY 23 est $59,732,359.00; FY 24 est $54,076,786.00; FY 21$102,767,733.00; FY 20$105,671,894.00; FY 19$63,955,076.00; FY 18$68,070,710.00; FY 17$67,822,327.00; FY 16$66,330,338.00; -
Range and Average of Financial Assistance
Range from $100,000 per year to $1,000,000 per year over a 5-year period.
Regulations, Guidelines and Literature
Regulations, Guidelines and Literature sources are specified in the individual relevant Broad Agency Announcements. The DoDGARS (as updated through DoD's interim implementation of 2 CFR part 200 which can be found at 2 CFR part 1103) applies to DoD grants and cooperative agreements.
Examples of Funded Projects
Fiscal Year 2023 Continued to fund ongoing research projects in fundamental research as well as two cooperative agreements that encompass a consortia of universities. One example is for DTRA Grant HDTRA12210024 to McLean Hospital, for the Assessing the Impact of Acetylcholinesterase Inhibition on Cognition and Brain Neurochemistry.


Federal Grants Resources