Trans-NIH Research Support


To provide support for new initiatives designed to address major opportunities and gaps in biomedical research that no single NIH institute could address alone, but which the agency as a whole can pursue to stimulate the progress of biomedical research and to catalyze changes that will serve to transform new scientific knowledge into tangible benefits for public health. Information on recent and current initiatives is available at

General information about this opportunity
Last Known Status
Program Number
Federal Agency/Office
Agency: Department of Health and Human Services
Office: National Institutes of Health
Type(s) of Assistance Offered
Program Accomplishments
Not Applicable.
Public Health Service Act, Title IV, Section 402A, Public Law 109-482, 42 U.S.C 282A.
Who is eligible to apply/benefit from this assistance?
Applicant Eligibility
Awards can be made to domestic, public or private, for-profit or nonprofit organization, university, college, hospital, laboratory, or other institution, including State and local units of government, and individuals. Some initiatives will accept applications from foreign organizations. Additional details on eligibility are specified in the Common Fund Grants and Funding Opportunities funding announcement, listed at
Beneficiary Eligibility
Institutions as described above.
Applications must be submitted in compliance with instructions provided with each initiative. 2 CFR 200, Subpart E - Cost Principles applies to this program.
What is the process for applying and being award this assistance?
Pre-Application Procedure
Preapplication coordination is not applicable. Environmental impact information is not required for this program. This program is excluded from coverage under E.O. 12372.
Application Procedure
2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. Prepare and submit applications according to instructions provided in the applicable Common Fund Grants and Funding Opportunities announcement, located at . This program is subject to the provisions of 45 CFR 75 including applicable federal cost principles as referenced, the NIH Grants Policy Statement, and the provisions in the funding announcement. NIH is transitioning to an electronic application by grant mechanism. Details, including the appropriate application form, can be found at
Award Procedure
Applications are reviewed for scientific and technical merit by a scientific review group and for program relevance by a national advisory council/board.
Contact the headquarters or regional office, as appropriate, for application deadlines.
Approval/Disapproval Decision Time
The length of the review cycle is four to nine months.
A principal investigator may question the substantive or procedural aspects of the review of his/her application by communicating with the NIH Scientific/Research contact, as provided on an initiative. A description of the NIH Peer Review Appeal procedures is available on the NIH Web site at .
Renewal (competing continuation, type 2) applications to Common Fund programs are not accepted unless specifically accepted by NIH staff.
How are proposals selected?
Funding decisions are based on scientific merit (42 CFR 52h) and program relevance. Scientific merit review encompasses: the peer review criteria detailed in the specific funding announcement, as well as the significance, approach, and innovation of the proposed research; the competency of the principal investigator; the adequacy of the resources and environment; the proposed budget and requested period of support; and, where applicable, the adequacy of the measures for protecting against adverse effects upon humans, animals, or the environment.
How may assistance be used?
To support research and other projects that will accelerate fundamental biomedical discovery and translation of that knowledge into effective prevention strategies and new treatments.
What are the requirements after being awarded this opportunity?
Annual progress reports and selected financial reports are required for continuing projects. Final progress reports, invention statements, and expenditure reports are required at the end of the projects. Cash reports are not applicable. Annual progress reports and selected financial reports are required for continuing projects. Final progress reports, invention statements, and expenditure reports are required at the end of the projects. Expenditure reports are not applicable. Performance monitoring is not applicable.
In accordance with the provisions of 2 CFR 200, Subpart F - Audit Requirements, non-Federal entities that expend financial assistance of $750,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Non-Federal entities that expend less than $750,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in 2 CFR 200.503.
Grantees generally must retain financial and programmatic records, supporting documents, statistical records, and all other records that are required by the terms of a grant, or may reasonably be considered pertinent to a grant, for a period of 3 years from the date the annual FSR is submitted. For awards under SNAP (other than those to foreign organizations and Federal institutions), the 3-year retention period will be calculated from the date the FSR for the entire competitive segment is submitted. Those grantees must retain the records pertinent to the entire competitive segment for 3 years from the date the FSR is submitted to NIH. Foreign organizations and Federal institutions must retain records for 3 years from the date of submission of the annual FSR to NIH. See 45 CFR 75 and 92.42 for exceptions and qualifications to the 3-year retention requirement (e.g., if any litigation, claim, financial management review, or audit is started before the expiration of the 3-year period, the records must be retained until all litigation, claims, or audit findings involving the records have been resolved and final action taken). Those sections also specify the retention period for other types of grant-related records, including F&A cost proposals and property records. See 45 CFR 75 and 92.36 for record retention and access requirements for contracts under grants. In accordance with 4 Code of Federal Regulations, Part 75, the HHS Inspector General, the U.S. Comptroller General, or any of their duly authorized representatives have the right of timely and unrestricted access to any books, documents, papers, or other records of recipients that are pertinent to awards in order to make audits, examinations, excerpts, transcripts, and copies of such documents. This right also includes timely and reasonable access to a recipient’s personnel for the purpose of interview and discussion related to such documents. The rights of access are not limited to the required retention period, but shall last as long as records are retained.
Other Assistance Considerations
Formula and Matching Requirements
Statutory formulas are not applicable to this program.
Matching requirements are not applicable to this program.
MOE requirements are not applicable to this program.
Length and Time Phasing of Assistance
Almost all awards are made for at least one year, with additional support (up to four more years) depending on the recommendation of the scientific review group, the national advisory council, successful annual performance, and availability of funds. See the following for information on how assistance is awarded/released: drawn from established accounts.
Who do I contact about this opportunity?
Regional or Local Office
See Regional Agency Offices. Director of the Office of Strategic Coordination, phone 301-402-7617.
Headquarters Office
Elizabeth Wilder Building One, Room 201, Bethesda, Maryland 20892 Email: Phone: (301) 402-7617 Fax: (301) 435-7268.
Website Address
Financial Information
Account Identification
(Project Grants) FY 14 $452,656,000; FY 15 est $499,586,000; and FY 16 est $519,586,000
Range and Average of Financial Assistance
$10,000 to $15,462,500 with the average being $737,000.
Regulations, Guidelines and Literature
Not Applicable.
Examples of Funded Projects
Not Applicable.


Federal Grants Resources