Targets of Low Dose Alcohol in the Brain (R21)


This Funding Opportunity Announcement (FOA) solicits research grant applications that define molecular and cellular targets mediating alcohol effects at concentrations of 10 mM and below. It has been well established that alcohol at relatively high concentrations modulate a variety of receptors and ion channels, intracellular signaling cascades, and gene expression in the brain. Significant knowledge gaps, however, remain in understanding how the brain responds to low doses of alcohol and what molecular targets mediate alcohol action at concentrations below 10 mM. The purpose of this FOA is to support research efforts to identify targets mediating effects of low-dose alcohol at molecular, cellular, and circuit levels.

General information about this opportunity
Last Known Status
Program Number
Federal Agency/Office
Agency: Department of Health and Human Services
Office: National Institutes of Health
Type(s) of Assistance Offered
Who is eligible to apply/benefit from this assistance?
Applicant Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
What is the process for applying and being award this assistance?
Other Assistance Considerations
Formula and Matching Requirements
This program does not have cost sharing or matching requirements.
Who do I contact about this opportunity?
Headquarters Office
NIH OER Webmaster
Website Address
E-mail Address
Financial Information
Range and Average of Financial Assistance
Awards up to $200,000.00


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