Research, Prevention, and Education Programs on Lyme Disease in the United States


To develop, implement and evaluate practical and effective measures for the primary and secondary prevention of Lyme disease in the United States.

General information about this opportunity
Last Known Status
Program Number
Federal Agency/Office
Agency: Department of Health and Human Services
Office: Centers for Disease Control and Prevention
Type(s) of Assistance Offered
Cooperative Agreements (Discretionary Grants)
Program Accomplishments
Fiscal Year 2014: NA. Fiscal Year 2015: Program is considering other concepts pending availability of funds that may include expanded community-based Integrated Tick Management studies, cause of Lyme-like illness in southern states, a study to evaluate Borrelia miyamotoi as a cause of human illness in the U.S., and multi-center diagnostic study for new Lyme tests. Fiscal Year 2016: No Current Data Available
Public Health Service Act, Section 301, 42 U.S.C 241(a).
Who is eligible to apply/benefit from this assistance?
Applicant Eligibility
Public and nonprofit organizations able to provide services to geographical areas where Lyme disease is endemic or found to be newly emerging in the continental United States. Thus, universities, colleges, research institutions, State and local health departments, and private nonprofit organizations are eligible.
Beneficiary Eligibility
States, political subdivisions of states, and other public and nonprofit private entities and the general public who may be exposed to the threat of Lyme disease in certain geographical areas.
Nonprofit organizations are corporations or associations no part of whose net earnings may lawfully inure to the benefit of any private shareholder or individual. Proof of nonprofit status must be submitted by private nonprofit organizations with the application or, if previously filed with PHS, the applicant must state where and when the proof was submitted. This program is excluded from coverage under 2 CFR 200, Subpart E - Cost Principles.
What is the process for applying and being award this assistance?
Pre-Application Procedure
This program has no preapplication requirements. Environmental impact information is not required for this program. This program is eligible for coverage under E.O. 12372, "Intergovernmental Review of Federal Programs." An applicant should consult the office or official designated as the single point of contact in his or her State for more information on the process the State requires to be followed in applying for assistance, if the State has selected the program for review.
Application Procedure
2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. To apply to published funding opportunity, applications must be submitted electronically through ( using the SF424 Research and Related (R&R) forms and the SF424 (R&R) Application Guide. Detailed application instructions are included in the Funding Opportunity Announcements (FOAs) for federal assistance. Submit the signed original and five copies of your application by mail or express delivery service to: Technical Information Management System, (Add FOA number here), CDC Procurement and Grants Office, U.S. Department of Health and Human Services, 2920 Brandywine Road, Atlanta, GA 30341. This program is subject to the provisions of 45 CFR 92 for State and local governments and OMB Circular No. A-110 for nonprofit organizations.
Award Procedure
Upon receipt, applications will be evaluated for completeness and responsiveness by the agency program and HHS/CDC Procurement and Grants Office (PGO). HHS/CDC will not review incomplete and non-responsive applications. After review and approval, a notice of grant award (NoA) is prepared and processed, along with appropriate notification to the public. Initial award provides funds for first budget period (usually 12 months) and NoA indicates support recommended for the remainder of project period, allocation of Federal funds by budget categories, and special conditions, if any.
Contact the headquarters or regional office, as appropriate, for application deadlines.
Approval/Disapproval Decision Time
Approximately 3 to 6 months.
Not Applicable.
Cooperative agreement project periods are for 3 to 4 years. Subject to availability of funds, after initial awards, projects may be renewed non-competitively contingent upon satisfactory progress by the recipient (as documented in required reports) and the determination that continued funding is in the best interest of the Federal government.
How are proposals selected?
Applications for public health research grants and cooperative agreements are evaluated for scientific and technical merit through the HHS/CDC peer review system. Applications are evaluated by a chartered Special Emphasis Panel in accordance with the Federal Advisory Committee Act, and in accordance with CDC peer review policy and manual.
Applications will be evaluated on the review criteria described in the Funding Opportunity Announcements (FOAs). In general, the review and selection process of complete and responsive applications to the FOA consists of determination of the scientific merit by peer review, availability of funds, and relevance of program priorities and the priorities of DHHS. Refer to the FOA for additional review criteria.
How may assistance be used?
Funding opportunities are made available to develop disease surveillance, conduct ecological and epidemiological studies, develop prevention and control activities, develop better diagnostic tests, and develop and disseminate educational materials and programs. Grants include funds for direct costs, i.e., personnel, travel, equipment, supplies, necessary to carry out an approved project as well as funds for the reimbursement of applicable indirect costs. Unallowable costs, such as reimbursement of pre-award costs, as well as those for which prior written approval is required, are indicated in the Public Health Service (PHS) Grants Policy Statement (
What are the requirements after being awarded this opportunity?
Program reports are not applicable. Cash reports are not applicable. An original and two hard-copies of the Non-Competing Grant Progress Report (PHS 2590) are due no less than 120 days prior to the end of each budget period within the project period. Financial status reports are required no later than 90 days after the end of each budget period. Final financial status reports are required no more than 90 days after the end of the project period. Final performance reports are required no more than 90 days after the end of the project period. All reports must be submitted to the Grants Management Specialist indicated in the NoA.
In accordance with the provisions of 2 CFR 200, Subpart F - Audit Requirements, non-Federal entities that expend financial assistance of $750,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Non-Federal entities that expend less than $750,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in 2 CFR 200.503.
Financial records, supporting documents, statistical records, and all other records pertinent to the project must be kept readily available for review by personnel authorized to examine PHS grant accounts. Records must be maintained for a minimum of 3 years after the end of a budget period. If questions still remain, such as those raised as a result of an audit, records must be retained until completion or resolution of any audit in process or pending resolution. Property records must be retained in accordance with PHS Grants Policy Statement requirements.
Other Assistance Considerations
Formula and Matching Requirements
This program has no statutory formula.
This program has no matching requirements.
This program does not have MOE requirements.
Length and Time Phasing of Assistance
Assistance is available for a 12-month budget period within project periods ranging from 3 to 4 years. See the following for information on how assistance is awarded/released: After awards are issued, funds are released in accordance with the payment procedure established by the grantee institution with DHHS, which may be an Electronic Transfer System or a Monthly Cost Request System.
Who do I contact about this opportunity?
Regional or Local Office
See Regional Agency Offices. Bacterial Diseases Branch, Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Office of Infectious Diseases, Centers for Disease Control and Prevention, 3156 Rampart Road, Fort Collins, CO 80521. Branch Extramural Activities Contacts: Ms. Diane Hamm - Telephone: (970) 221-6414 and Dr. Charles B. (Ben) Beard - Telephone: (970) 221- 6418. Division Extramural Activities Contacts: Mr. Leo Weakland - Telephone: (970) 221-6426 or Dr. Lyle R. Petersen - Telephone: (970) 221-6428.
Headquarters Office
Christine Morrison 1600 Clifton Road, E60, Atlanta, Georgia 30329-4018 Email: Phone: 404-718-8845 Fax: 404-718-8640
Website Address
Financial Information
Account Identification
(Cooperative Agreements (Discretionary Grants)) FY 14 $675,000; FY 15 Estimate Not Available; and FY 16 Estimate Not Available - These obligations exclude federal assistance provided to the States through the Epidemiology and Laboratory Capacity (ELC) and Emerging Infections Program (EIP) cooperative agreements (covered under CFDA 93.283), and their supporting large contract(s) provided by program discretionary funds.
Range and Average of Financial Assistance
$250,000 to $300,000; Average award depends on funding opportunity announcement.
Regulations, Guidelines and Literature
PHS Grants Policy Statement, DHHS Publication No. (OASH) 94-50,000 (Rev.) April 1, 1994. Pertinent information may be obtained by contacting the Headquarters Office.
Examples of Funded Projects
Not Applicable.


Federal Grants Resources