Research Infrastructure Programs


The Office of Research Infrastructure Programs (ORIP) is a program office in the Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) dedicated to supporting research infrastructure and related research programs. ORIP consists of the Division of Comparative Medicine (DCM); and Division of Construction and Instruments (DCI).

General information about this opportunity
Last Known Status
Program Number
Federal Agency/Office
National Institutes of Health, Department of Health and Human Services
Type(s) of Assistance Offered
B - Project Grants
Program Accomplishments
Not applicable.
Small Business Research and Development Enhancement Act of 1992, Public Law 102-564
Public Health Service Act, Title IV, Section 487, Public Law 99-158
Public Health Service Act, Title III, Section 301, Public Law 78-410, 341 U.S.C. 287-288
Who is eligible to apply/benefit from this assistance?
Applicant Eligibility
Institutions of higher education, hospitals, and other institutions and organizations, both nonprofit and for-profit, seeking to establish, continue, or enlarge programs consistent with the objectives of the program. Applicants for NRSA must be citizens of the United States or be admitted to the United States for permanent residency. Applicants must be nominated and sponsored by a public or private nonprofit institution with staff and facilities suitable for the proposed research training. Nonprofit domestic organizations may apply for the institutional NRSA. Research Career Development: Applications may be submitted on behalf of candidates by domestic, nonfederal organizations, public or private institutions of higher education.
Beneficiary Eligibility
Biomedical investigators at any nonprofit or for-profit organization, company, or institution engaged in biomedical research.
Not applicable.
What is the process for applying and being award this assistance?
Pre-Application Procedure
Preapplication coordination is required. Contact the headquarters, as appropriate.
Application Procedure
2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. Application forms may be obtained from the Division of Extramural Outreach and Information, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910. Telephone (301) 435-0714, e-mail: . Completed applications should be submitted to the Center for Scientific Review, 6701 Rockledge Drive, MSC 7710, Bethesda, MD 20892-7710. The standard application forms PHS 398, (Rev. November 1998), as furnished by PHS and required by 45 CFR, Part 92 must be used for all programs. For filing NRSA individual fellowship award applications, Form 416-1 (Rev. October 1991) is needed.
Award Procedure
The initial review of applications from eligible investigators and institutions is reviewed by committees comprised of authorities in various fields of biomedical research and science education, as appropriate. Each application is given a peer evaluation for merit, and recommendations are forwarded to the Council of Councils for final review and recommendation.
Contact the headquarters or regional location, as appropriate for application deadlines
Approval/Disapproval Decision Time
More than 180 days.
From 60 to 90 days. A principal investigator (P.I.) may question the substantive or procedural aspects of the review of their application by communicating with the NIH staff. A description of the NIH Peer Review Appeal procedures is available on the NIH home page .
More than 180 days. Renewal applications are reviewed in the same manner as new applications. Modernization and Instrumentation: None.
How are proposals selected?
The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives.
How may assistance be used?
The Division of Comparative Medicine (DCM) helps meet the needs of biomedical researchers for high-quality, disease-free animals and specialized animal research facilities. Additionally, DCM seeks to increase small business participation in federally supported research and development as well as the private-sector commercialization of technology developed with federal support and the biomedical workforce of scientist with a background in veterinary medicine. It does this through the federal government's Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. Division of Construction and Instruments: This Division supports programs to expand the Nation’s capacity for the conduct of biomedical research by offering grants for the acquisition of state-of the-art biomedical research instrumentation and integrated instrument systems, and grants to renovate, improve, or modernize existing research facilities.
What are the requirements after being awarded this opportunity?
Not applicable.
In accordance with the provisions of 45 CFR 75, nonfederal entities that expend financial assistance of $500,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Nonfederal entities that expend less than $500,000 a year in Federal awards are exempt from Federal audit requirements for that year. The regulation provides for profit organizations with the option for the type of audit that will satisfy the audit requirement that a financial related audit of the HHS awards in accordance with Government Auditing Standards In accordance with NIH grants policy, Foreign grantees are subject to the same audit requirements as for-profit (commercial) organizations.
Grantees generally must retain financial and programmatic records, supporting documents, statistical records, and all other records that are required by the terms of a grant, or may reasonably be considered pertinent to a grant, for a period of 3 years from the date the annual FSR is submitted. For awards under SNAP (other than those to foreign organizations and Federal institutions), the 3-year retention period will be calculated from the date the FSR for the entire competitive segment is submitted. Those grantees must retain the records pertinent to the entire competitive segment for 3 years from the date the FSR is submitted to NIH. Foreign organizations and Federal institutions must retain records for 3 years from the date of submission of the annual FSR to NIH. See 45 CFR 74.53 and 92.42 for exceptions and qualifications to the 3-year retention requirement (e.g., if any litigation, claim, financial management review, or audit is started before the expiration of the 3-year period, the records must be retained until all litigation, claims, or audit findings involving the records have been resolved and final action taken). Those sections also specify the retention period for other types of grant-related records, including F&A cost proposals and property records. See 45 CFR 74.48 and 92.36 for record retention and access requirements for contracts under grants. In accordance with 45 Code of Federal Regulations, Part 74.53(e), the HHS Inspector General, the U.S. Comptroller General, or any of their duly authorized representatives have the right of timely and unrestricted access to any books, documents, papers, or other records of recipients that are pertinent to awards in order to make audits, examinations, excerpts, transcripts, and copies of such documents. This right also includes timely and reasonable access to a recipient's personnel for the purpose of interview and discussion related to such documents. The rights of access are not limited to the required retention period, but shall last as long as records are retained.
Other Assistance Considerations
Formula and Matching Requirements
Statutory formula is not applicable to this assistance listing.

Matching requirements are not applicable to this assistance listing.

MOE requirements are not applicable to this assistance listing.
Length and Time Phasing of Assistance
All programs: 1 to 5 years. An Electronic Transfer System is used for transferring funds. Research Grants, Cooperative Agreements, Center Grants, and NRSA Institutional grants may be awarded for up to 5 years, generally in 12-month budget periods and may be extended through a competitive renewal. SBIR: Normally, Phase I awards are for 6 months; normally, Phase II awards are for 2 years. STTR: Normally, Phase I awards are for 1 year; normally, Phase II awards are for 2 years. Shared Instrumentation Grants are awarded for 12 months. The Council of Councils may recommend funding for periods ranging from 1 to 5 years. Funding commitments are made annually. Award length may vary depending on the recommendation of the scientific review group, the national advisory council, successful annual performance, and availability of funds. A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization. An Electronic Transfer System is used for transferring funds.
Who do I contact about this opportunity?
Regional or Local Office
None/Not specified.
Headquarters Office
Patricia Newman
6701 Democracy Boulevard
Room 956-MSC4874
Bethesda, MD 20892-4874 US
Phone: 3014350864
Website Address
Financial Information
Account Identification
(Project Grants) FY 18$267,342,483.00; FY 19 est $260,292,600.00; FY 20 est $260,292,600.00; FY 17$248,984,521.00; FY 16$265,638,377.00; - (Project Grants) FY 15 $264,543,192; FY 16 est $264,187,662; and FY 17 est $264,187,662- Amounts shown are actual/estimated amounts available for research grants including SBIR/STTR, centers, research career awards, and research project grants. Amounts for research training grants, R&D contracts, and research management support are not included.(Project Grants (Capacity Building and Complaint Processing, Training)) FY 18$7,366,915.00; FY 19 est $6,823,308.00; FY 20 est $6,823,308.00; FY 17$7,537,974.00; FY 16$7,659,219.00; - (Project Grants (Training)) FY 15 $6,514,392; FY 16 est $7,787,235; and FY 17 est $7,787,235 - Amounts shown are for individual and institutional research training awards.
Range and Average of Financial Assistance
Awards vary in range depending on the particular activity codes. Research Centers grants have much larger ranges - from hundreds of thousands to several million dollars. All costs are shown on a single year basis. Awards may be for up to five years.
Regulations, Guidelines and Literature
Reference: 44 FR 12368, March 6, 1979; Rev. No. 1, 47 FR 33658, August 3, 1982; Rev. No. 2, 51 FR 20908, June 9, 1986.Reference: 41 FR 32016, July 30, 1976. Reference: 34 CFR 255. 45 CFR 92. Reference: 42 FR 45828. 42 CFR 52h. Grants will be available under the authority of and administered in accordance with the PHS Grants Policy Statement and Federal Regulations at 42 CFR 52 and 42 USC 241. Department Staff Manual "Grants Administration"; Indirect Cost Register, DHHS; PHS Grants Policy Statement, DHHS Publications No. (OASH) 94-50,000, (Rev.) April 1, 1994; "NIH Grants Policy Guide," Office for Protection from Research Risks, NIH; "A Guide to Grant and Award Programs of the NIH"; and miscellaneous program literature from Headquarters Office.
Examples of Funded Projects
Not applicable.


Federal Grants Resources