Molybdenum-99 Program


The U.S. Department of Energy (DOE) National Nuclear Security Administration?s (NNSA) Office of Material Management and Minimization (NA-23) is leading the effort to demonstrate and achieve commercial-scale production of the medical isotope, Molybdenum-99, hereafter referred to as Mo-99, without the use of highly enriched uranium (HEU) in the United States. Mo-99 is a critical radioisotope whose decay byproduct technetium-99m (Tc-99m), is used in approximately 40,000 nuclear medicine diagnostic procedures performed daily in the United States. Its primary uses include diagnosing heart disease, treating cancer, and studying organ structure and function. The isotope?s short half-life and excellent binding properties make it uniquely suited for medical procedures. However, due to its short half-life it must be produced continuously to meet the medical community?s requirements. The United States does not currently have a domestic production capability for Mo-99 sufficient to meet the needs of the U.S. healthcare community, currently estimated at 4,500 6-day curies per week. Until any U.S. producer enters the market, the United States must import all of its supply from foreign producers, which in some instances use proliferation-sensitive HEU in its production processes. The establishment of reliable, commercial, non-HEU-based Mo-99 production in the United States complements the long-standing U.S. policy to minimize and eliminate the use of proliferation-sensitive HEU in civilian applications in order to prevent the potential theft of this material for malevolent use. The United States is at the nexus of two related priorities: the need to ensure a reliable, robust Mo-99 supply for U.S. patient care, and discouraging the use of proliferation-sensitive HEU in civilian applications. NNSA will issue Cooperative Agreements with the purpose of providing additional federal funding to accelerate commercial Mo-99 projects? time to market so that industry and government can fulfill these two critical priorities and decrease the U.S. medical community?s reliance on foreign supplies of Mo-99.

General information about this opportunity
Last Known Status
Program Number
Federal Agency/Office
National Nuclear Security Administration
Type(s) of Assistance Offered
B - Project Grants
Program Accomplishments
Not applicable.
Act to reorganize and consolidate certain functions of the Federal Government in a new Energy Research and Development Administration and in a new Nuclear Regulatory Commission in order to promote more efficient management of such functions., Title Energy Reorganization Act of 1974, Part Title I, Section Section 107 Public Law 93-438; 88 Stat. 1240, 42 U.S.C. 5817, Title I, Section 107, 93-438; 88 , Statute 1240,42, 5817, Public Law 5817-93-438
A United States federal law that covers for the development, regulation, and disposal of nuclear materials and facilities in the United States, Title Atomic Energy Act of 1954, Section Section 3157, Public Law 101-189, 103 Stat. 1684, 42 U.S.C. 2051 , Section 3157, 1684 Stat. 42, 2051 U.S.C , Section 3157, 101-189, 103 , Statute 1684,42, 2051 US Code 3157, Public Law 2051-101-189
A bill to establish a Department of Energy in the executive branch by the reorganization of energy functions within the Federal Government in order to secure effective management, to assure a coordinated National energy policy., Title Department of Energy (DOE) Organization Act of 1977, Public Law 42 U.S.C. 7101-95-91
AN ACT To establish a national program for research and development in nonnuclear energy sources., Title Federal Nonnuclear Energy Research and Development Act of 1974, Public Law -93-577
Directs the Secretary of Energy (DOE) to implement a technology-neutral program to evaluate and support projects for the production in the United States (except in certain circumstances without the use of highly enriched uranium) of significant quantities of molybdenum-99 for medical uses, implemented in cooperation with non-federal entities, whose costs shall be shared in accordance with certain cost sharing requirements of the Energy Policy Act of 2005., Title The American Medical Isotopes Production Act of 2012, Public Law -112-239
Who is eligible to apply/benefit from this assistance?
Applicant Eligibility
U.S. commercial entities with existing technologies to achieve commercial-scale production of Mo-99 in the U.S. National Laboratories, M&O Contractors, Institutions of Higher Education, and Federally Funded Research and Development Centers (FFRDC) are not eligible to apply for an award under this FOA, but can be included in teaming arrangements.
Beneficiary Eligibility
The general public.
For Non-government organizations, Costs will be determined in accordance with OMB Circular No. A-122 . 2 CFR 200, Subpart E - Cost Principles applies to this program.
What is the process for applying and being award this assistance?
Pre-Application Procedure
Preapplication coordination is required. An environmental impact statement is required for this listing.
Application Procedure
2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. Applications must be submitted through to be considered for award. You cannot submit an application through unless you are registered. Please read the registration requirements carefully and start the process immediately. Remember you have to update your SAM registration annually. If you have any questions about your registration, you should contact the Helpdesk at 1-800-518-4726 to verify that you are still registered in All applications that are received by the application due date and time, as specified in the FOA, will be subjected to an initial Compliance Review, and upon satisfactorily passing the initial review, will be subjected to a comprehensive evaluation. NOTE: Applications submitted via FedConnect will not be accepted
Award Procedure
The Merit Review Panel Chairperson will be responsible for reviewing the independent findings and ratings of each evaluator, and ultimately completing a Merit Review Panel Chairperson's Report to summarize the findings and make recommendations for awards to the Selection Official. The Selection Official will consider the merit review recommendation, program policy factors, budget evaluations of the Project Management Plan, and the amount of funds available, when making a decision for awards. The program policy factors and budget evaluations will not be point scored, but the Selection Official may consider them in making the selections for negotiation of award. The Selection Official will make a decision to select for award a group of projects which represents a diversity of technical approaches, methods, applications and/or market segments, which will likely include 1-4 awards. Upon the Selection Official making the final decisions, the Contracting Officer will notify selectee's and non-selectee's.
FOA will be open for 60 days
Approval/Disapproval Decision Time
30 Days - Selection Process 135 Days - Prepare for Award/Negotiate/Award 1 - 4 Cooperative Agreements
Not applicable.
Not applicable.
How are proposals selected?
All timely applications that satisfactorily pass the initial compliance review will be eligible for a comprehensive merit review. Prior to conducting the comprehensive merit review, an initial review will be performed to determine whether: (1) the applicant is eligible for award; (2) the information required by the FOA has been submitted; (3) all other mandatory requirements of the FOA are satisfied; and (4) the proposed project is responsive to the program objectives of the FOA. This review will be a thorough, consistent, and objective examination of applications based on the pre-established evaluation criteria set forth in the FOA. Each application will be evaluated on the strengths and weaknesses it exhibits in relation to scientific and technological merit; technical approach; and business strategy and management capabilities.
How may assistance be used?
Only domestic (U.S.) entities with existing projects to achieve full-scale commercial production of Molybdenum-99 in the United States in accordance with the goals of the program may submit applications. Any U.S. commercial entity with an existing project that plans to produce in the United States without the use of HEU is eligible to apply.
What are the requirements after being awarded this opportunity?
Performance Reports: Final Report is required
In accordance with 2 CFR Part 200 as amended by 2 CFR Part 910, DOE reserves the right to initiate a final incurred cost audit on this award. If the audit has not been performed or completed prior to the closeout of the award, DOE retains the right to recover an appropriate amount after fully considering the recommendations on disallowed costs resulting from the final audit
Records of all project costs that are claimed as cost sharing, including in-kind costs, as well as records of costs to be paid by DOE/NNSA must be maintained.
Other Assistance Considerations
Formula and Matching Requirements
Statutory formula is not applicable to this assistance listing.

Matching is mandatory. 50%. Cooperative agreements (CA) will be awarded on a 50%/50% Federal/non-Federal cost sharing basis . The recipient will be required to match the U.S. Government contribution.

MOE requirements are not applicable to this assistance listing.
Length and Time Phasing of Assistance
Generally, grants are approved for two-year or five year project periods and either fully funded or funded per budget period, depending on budget appropriation, at the discretion of the program office. A merit review team will be established of Technical Reviewers to conduct independent comprehensive reviews of each application. Selected proposals will be negotiated for award. Award amounts are typically funded based on available appropriations.
Who do I contact about this opportunity?
Regional or Local Office
None/Not specified.
Headquarters Office
Crystal Trujillo
1000 Independence Ave,. SW
Washington, DC 20585 USA
Phone: 202-586-8572
Website Address
Financial Information
Account Identification
(Cooperative Agreements) FY 19$0.00; FY 20 est $0.00; FY 21 est $35,000,000.00; -
Range and Average of Financial Assistance
$5M - $35M
Regulations, Guidelines and Literature
2 CFR Part 200 as amended by 2 CFR Part 910 The authority for this financial assistance action is the Department of Energy Act of 1977 (Public Law 95-91); the Federal Grant and Cooperative Agreement Act of 1977 (Public Law 95-224), as amended by (Public Law 97-258); and 10 CFR 600.6(b). Signed into law on January 2, 2013, The American Medical Isotopes Production Act of 2012 (Title XXXI, Subtitle F, National Defense Authorization Act for Fiscal Year 2013, [Public Law 112-239]) (AMIPA)
Examples of Funded Projects
Not applicable.


Federal Grants Resources