Medical Library Assistance


To meet a growing need for investigators trained in biomedical informatics research and data science by training qualified pre- and post-doctoral candidates; to conduct research in biomedical informatics, bioinformatics and related computer, information and data sciences; to facilitate management of electronic health records and clinical research data; to prepare scholarly works in biomedicine and health; to advance biocomputing and bioinformatics through participation in Federal initiatives relating to biomedical informatics, bioinformatics and biomedical computing; and to stimulate and foster scientific and technological innovation through cooperative research development carried out between small business concerns and research institutions, through Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grants.

General information about this opportunity
Last Known Status
Program Number
Federal Agency/Office
National Institutes of Health, Department of Health and Human Services
Type(s) of Assistance Offered
B - Project Grants
Program Accomplishments
Fiscal Year 2016 300 new and continuing applications will be received. 130 new and continuing awards will be made. NLM received over 270 competing applications; of those 229 were reviewed and 47 awards were issued. NLM funded 101 noncompeting renewal applications. A total of 148 new and continuing awards were issued. The overall success rate was 13.5%.
Fiscal Year 2017 320 new and continuing applications will be received. 150 new and continuing awards were issued.
Fiscal Year 2019 474 new and continuing applications were received. 188 new and continuing awards were made.
Fiscal Year 2020 450 new and continuing applications were received. 160 new and continuing awards will be made.
Fiscal Year 2023 409 new and continuing applications were received, 119 new and continuing awards will be made.
Public Health Service Act, Title IV, Part D, Subpart 2, Section 472-476
Public Health Service Act, Title III, Part A, Section 301
Who is eligible to apply/benefit from this assistance?
Applicant Eligibility
Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the project director/principal investigator (PD/PI) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. See Beneficiary Eligibility below for further details.
Beneficiary Eligibility
Research Grants are available to public or private, domestic or foreign, for profit or not-for-profit institutions or organizations with research capabilities in biomedical informatics, bioinformatics, computer sciences, information sciences, data sciences and related disciplines. Training Grants may be made to nonfederal public and nonprofit private institutions. With the exception of NIH Pathway to Independence awards, trainees must be citizens or non-citizen nationals of the United States or have been lawfully admitted to the United States for permanent residence. Resource grants (Information Resource, Scholarly Works) are open to any U.S. public or private nonprofit institution or organization. SBIR and STTR grants can be awarded only to domestic small businesses (entities that are independently owned and operated for profit, are not dominant in the field in which research is proposed, and have no more than 500 employees). To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council.
This program is subject to the Uniform Guidelines (2 CFR 200), Subpart E - Cost Principles. These guidelines consolidate all cost principles, audit and administrative requirements for Federal grants and cooperative agreements. 2 CFR 200, Subpart E - Cost Principles applies to this program.
What is the process for applying and being award this assistance?
Pre-Application Procedure
Preapplication coordination is not applicable.
Application Procedure
2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. 2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. Generally, electronic applications are accepted for Research & Training Grants, SBIR and STTR grants, Resource Grants as well as Fellowship awards. Electronic grant submission of the SF424 (R&R) form is via For instructions on submitting grants electronically, see These programs are subject to the provisions of 45 CFR Part 75 as applicable. Updates on NLM application deadlines and links to available forms can also be found at
Award Procedure
Research, training, career development and resource applications are evaluated for merit by a committee of scientific experts and for program relevance by the Board of Regents (BOR) of the National Library of Medicine (NLM). If favorably recommended, the applications are considered for funding. An award notice is prepared when it is determined that a grant is to be paid. All accepted SBIR/STTR applications are evaluated for scientific and technical merit by an appropriate scientific peer review panel and by Board of Regents (BOR). All applications receiving a priority score compete for available SBIR/STTR set-aside funds based on scientific and technical merit and commercial potential of the proposed research, program relevance, and portfolio balance among the areas of research.
Contact the headquarters or regional location, as appropriate for application deadlines
Approval/Disapproval Decision Time
More than 180 days. From 9-10 months after the application deadline.
NIH policy allows a principal investigator (PI) to appeal the outcome of a review if procedural errors or factual errors entered into the review of the application. A description of the NIH Peer Review Appeal procedures is available at However, differences of scientific opinion that often occur between investigators and reviewers may not be contested through these procedures. In addition, communications from investigators consisting of additional information that was not available to the reviewers are not considered to be appeals. The updated NIH policy on submission of grant applications, including resubmissions, can be found at:
More than 180 days. Competing renewal applications follow the same review procedures as new applications; dates for submission are at NIH also permits the resubmission of an application that has been revised following merit review. Deadlines for resubmissions are listed with other deadlines. Applicants should consult the funding opportunity announcement to find out if renewals are allowed for that grant program.
How are proposals selected?
The standard NIH review criteria, significance, investigator, innovation, approach and environment are used as the basis of merit review. Considerations for final award decisions include level of innovation, program priority, portfolio balance, and availability of funds. For NLM resource grants, review criteria include considerations as to relevance to program objectives, impact on the management and transmission of biomedical knowledge, institutional readiness and resources available to project, expertise of project director and key personnel, scientific or technical merit of project, sustainability of what is deployed, and appropriateness of budget. For Career awards, review criteria include issues pertaining to the suitability of the candidates and their career development plan, research plan, mentors/consultants/collaborators, as well as the environment and institutional commitment to the candidates. For Training awards, review criteria include evidence of soundness in the areas of: Training Program and Environment, Training Program Principal Investigator(s), Preceptors and Mentors, Trainees, and Training Record. Comparative priorities on the above criteria are based on collective judgment of peer reviewers. The following criteria are used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the scientific, technical, or technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications are reviewed based upon similar criteria, and on the degree to which the Phase I objectives were met and feasibility demonstrated.
How may assistance be used?
RESEARCH GRANT PROGRAMS: Research Grants are available for fundamental and applied research in biomedical informatics and data science. Areas of research interest include: representation, organization and retrieval of biomedical and biological knowledge, data and images; enhancement of human intellectual capacities through virtual reality, dynamic modeling, artificial intelligence, and machine learning; medical decision-making; linguistic analyses for natural language processing and understanding; informatics topics relevant to public health, consumer information and disaster information management. Research Project Grants (R01) are available for rigorous scientific research studies and experiments. From time to time, NLM issues Requests for Applications and Notices of Special Interest for innovative informatics and data science research in special priority areas. Exploratory/Developmental Grants (R21) support early, conceptual work and feasibility tests. Other research grants include Informatics Conference Grants (R13) and several NIH-wide grant programs on high priority topics such as health literacy, behavioral research, health disparity, climate change, and detection of gene environment interactions for complex human diseases. Further information on research grants is available at TRAINING GRANT PROGRAMS: NLM's University-based Biomedical Informatics Research Training Programs (T15) promote the training of talented individuals who seek research careers in biomedical informatics, translational bioinformatics, clinical research informatics, public health informatics and data science. A competition for these institution-based training grants is announced every five years. The most recent competition was held in 2016. University-based training support may be at the pre- or post-doctoral level. Training sites recruit and choose their trainees, and are expected to have well-established computing resources, strong informatics research and education programs, experienced faculty and staff committed to research in the field of biomedical informatics and/or biomedical computing, and available courses or experience in biomedical informatics, information science, and cognitive sciences. Institutional training grants provide trainee stipends, tuition and fees, travel, and certain institutional support costs. Further information on training grants is available at CAREER DEVELOPMENT GRANT PROGRAMS: NLM offers NIH Pathway to Independence awards (K99/R00) that are reserved for investigators who are making the transition to their first research positions. These grants can last up to five years. They include a mentored period, followed by an unmentored period, and provide both salary and research support. Further information on career development grants is available at DIVERSITY and RE-ENTRY SUPPLEMENTS: Research supplement awards are offered to promote diversity in health-related informatics and data science research, and to promote re-entry into informatics and data science careers. Diversity and re-entry awards are issued as supplements to existing research grants funded by NLM. RESOURCE GRANT PROGRAMS: NLM funds cooperative agreements (UG4) to support Regional Medical Libraries (RMLs) as an integral component of the Network of the National Library of Medicine (NNLM). The goal of the NNLM is to advance the progress of medicine and improve public health by providing U.S. health professionals with equal access to biomedical information, and to improve individuals’ access to information to enable them to make informed decisions about their health. The RMLs coordinate the operation of the network of libraries and other organizations that make up the NNLM. NLM Information Resource Grants to Reduce Health Disparities (G08) support implementation projects that bring useful, usable health information to health disparity populations and their health care providers. NLM offers Grants for Scholarly Works (G13) to support preparation of books in the history and philosophy of biomedicine, bioethics, and public policy areas of importance to health professionals and biomedical scientists. The purpose, requirements, funding periods and award limits vary for these grant programs and are described in the funding opportunity announcements (FOAs). Further information on resource grants is available at SMALL BUSINESS RESEARCH & DEVELOPMENT GRANT PROGRAMS: Small Business Innovation Research (SBIR) and Small Business Technology Transfer Research (STTR) grants are made to U.S. small businesses that seek to undertake informatics and data science research and development leading to commercialization. The STTR program requires a small business applicant organization to formally collaborate with a research institution in Phase I and Phase II. SBIR Phase I grants are to establish the technical merit and feasibility of a proposed research effort that may lead to a commercial product or process. Phase II grants are for the continuation of the research initiated in Phase I and that are likely to result in commercial products or processes. STTR Phase I grants are to determine the scientific, technical, and commercial merit and feasibility of the proposed cooperative effort that has potential for commercial application. Phase II funding is based on results of research initiated in Phase I, and scientific and technical merit and commercial potential of the proposed project in Phase II application. Further information on SBIR/STTR grants is available at
What are the requirements after being awarded this opportunity?
Not applicable.
In accordance with the provisions of 2 CFR 200, Subpart F - Audit Requirements, non-Federal entities that expend financial assistance of $750,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Non-Federal entities that expend less than $750,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in 2 CFR 200.503. All audit requirements for this program are defined in 2 CFR 200, Subpart F - Audit Requirements.
Financial and programmatic grant records must be retained for three (3) years from the day on which the grantee submits the final Federal Financial Report (FFR). The beginning date for record retention purposes is the date of the FFR submission for the competitive segment of the grant.
Other Assistance Considerations
Formula and Matching Requirements
Statutory formula is not applicable to this assistance listing.

Matching requirements are not applicable to this assistance listing.

MOE requirements are not applicable to this assistance listing.
Length and Time Phasing of Assistance
The length of a grant award varies by the type of grant. R01 research grants generally last three or five years. Resource grants, Exploratory/Developmental grants, and Career Transition awards have defined maximum periods that are provided in the funding opportunity announcements. See the following for information on how assistance is awarded/released: A formal notification in the form of a Notice of Award will be provided to the successful applicant organization. A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization.
Who do I contact about this opportunity?
Regional or Local Office
None/Not specified.
Headquarters Office
Extramural Programs
Extramural Programs National Library of Medicine, National Institutes of Health, Public Health Service, Department of Health and Human Services, Bethesda, MD 20894. Telephone: (301) 496-4621.

Program Contact: Program Officer: Telephone: (301) 594-4882.

Grants Management Contact: Grants Management Officer: Telephone: (301) 496-4221.

Grant Review Contact: Scientific Review Officer: Telephone: (301) 594-4937.

Use the same numbers for FTS. Website:, Bethesda, Maryland 20892 Phone: (301) 496-4621
Bethesda, MD 20892 USA
Phone: (301) 496-4621

Amie Park
6705 Rockledge Drive, Suite 500V
Bethesda, MD 20892 USA
Phone: 301-594-3074
Fax: 301-402-2952
Website Address
Financial Information
Account Identification
(Project Grants) FY 22$58,581,621.00; FY 23 est $44,565,598.00; FY 24 est $44,565,598.00; FY 21$68,517,288.00; FY 20$69,224,137.00; FY 19$65,050,175.00; FY 18$61,842,104.00; FY 17$56,629,037.00; FY 16$42,276,400.00; - (Cooperative Agreements (Discretionary Grants)) FY 22$11,061,810.00; FY 23 est $11,061,810.00; FY 24 est $11,061,811.00; -
Range and Average of Financial Assistance
$6,000 to $1,600,000 (range); $405,191 - average cost for Research Grant (R01); $125,288 - average cost for Information Resource Grant (G08); $47,280 - average total cost for Scholarly Works Grant (G13)
Regulations, Guidelines and Literature
National Library of Medicine Grant Programs are awarded under the Public Health Service Act and the Medical Library Assistance Act. Grants and funding awards are made available under the authority of the Acts as codified under 45 CFR Part 75 (Uniform Administrative Requirements, Cost Principles, and Audit Requirements for HHS Awards); the NIH Grants Policy Statement is available to grantees as a single document governing the NIH/DHHS policy requirements and terms and conditions of NIH/DHHS grant awards. Additional regulations and guidelines are provided in the Omnibus Solicitation of the Public Health Service for Small Business Innovation Research (SBIR - R43, R44) Grant and Cooperative Agreement Applications including the Omnibus Solicitation of the National Institutes of Health for Small Business Technology Transfer (STTR - R41, R42) Grant Applications.
Examples of Funded Projects
Fiscal Year 2016 An ongoing list of NLM-awarded grants may be found at An ongoing list of NLM-awarded grants may be found at http://www.nlm.nih/gov/Awards2016.html.
Fiscal Year 2017 An ongoing list of NLM-awarded grants may be found at http://www.nlm.nih/gov/Awards2017.html.
Fiscal Year 2019 A list of NLM grants awarded may be found at
Fiscal Year 2020 A list of NLM grants awarded may be found at


Federal Grants Resources