Global Threat Reduction


The U.S. Department of State's Office of Cooperative Threat Reduction (ISN/CTR), part of the Bureau of International Security and Nonproliferation, supports programs aimed at reducing the threat posed by terrorist organizations or states of concern seeking to acquire weapons of mass destruction (WMD) expertise, material, and equipment. ISN/CTR programs, also known as Global Threat Reduction (GTR) programs, accomplish this task by funding a variety of projects that aim to enhance biological, chemical, and nuclear security practices and productively engage scientists with WMD-applicable expertise in civilian pursuits. In addition to continued efforts in the former Soviet Union to engage WMD experts, GTR programs are working to reduce the rapidly growing worldwide WMD threat posed by terrorists, non-state actors, and proliferant states. GTR programs are threat-driven and focus on frontline states and in regions where the terrorist threat is on the rise.

General information about this opportunity
Last Known Status
Program Number
Federal Agency/Office
Bureau of International Security and Nonproliferation, Department of State
Type(s) of Assistance Offered
B - Project Grants; Z - Salaries and Expenses
Program Accomplishments
Not applicable.
Foreign Assistance Act of 1961, as amended, Public Law 87-195, 22 U.S.C. 2349bb-1
Who is eligible to apply/benefit from this assistance?
Applicant Eligibility
Please see specific announcement on
Beneficiary Eligibility
Please see specific announcement on
As specified in specific requests for application (RFAs), applicants may be required to submit copies of their most recent negotiated indirect cost rate agreement (NICRA) to support proposed indirect costs. Additionally, applicants may be required to submit resumes, curricula vitae, or other supporting documentation showing that proposed key personnel are qualified to perform their intended roles.
What is the process for applying and being award this assistance?
Pre-Application Procedure
Preapplication coordination is not applicable.
Application Procedure
2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. Detailed application instructions will be specified in individual requests for application (RFAs). Please see specific announcement on
Award Procedure
ISN/CTR will evaluate applications for GTR assistance agreements consistent with the terms specified in individual requests for application (RFAs).
Not applicable.
Approval/Disapproval Decision Time
From 30 to 60 days. Please see specific announcement on
Not applicable.
Not applicable.
How are proposals selected?
Criteria for proposal selection is specified in individual requests for application (RFAs). See specific announcement at
How may assistance be used?
ISN/CTR periodically awards assistance instruments to facilitate the implementation of specific projects in various partner countries. Past GTR programs include: formal training workshops for foreign government officials on biological, chemical, and nuclear security; assistance developing curricula and training materials that institutionalize scientific ethics; and assessing partner countries' adherence to international best practices on WMD expertise and material security. ISN/CTR will release requests for application (RFAs) on an annual basis and as specific grant/cooperative agreement opportunities are identified.
What are the requirements after being awarded this opportunity?
Performance Reports: See individual announcements in for specific performance monitoring requirements.
Please see specific announcement on
Financial records are required to be maintained for three years.
Other Assistance Considerations
Formula and Matching Requirements
Statutory formula is not applicable to this assistance listing.

Matching requirements are not applicable to this assistance listing.

MOE requirements are not applicable to this assistance listing.
Length and Time Phasing of Assistance
ISN/CTR typically limits performance of individual assistance agreements to twelve months, though performance may be permitted beyond twelve months on a case-by-case basis depending on the complexity of the given project. Method of awarding/releasing assistance: Lump.
Who do I contact about this opportunity?
Regional or Local Office
None/Not specified.
Headquarters Office
Jonathon D. Walz
HST 3327 - ISN/CTR,
2201 C Street NW
Washington, DC 20520 US
Phone: 202-736-4961
Fax: 202-736-7698
Website Address
Financial Information
Account Identification
(Salaries and Expenses) FY 18$68,253,241.00; FY 19 est $16,572,086.00; FY 20 Estimate Not Available FY 16 est $35,000,000.00; FY 15 est $35,000,000.00; -
Range and Average of Financial Assistance
Typical award ammount is approximately $500,000.
Regulations, Guidelines and Literature
Not applicable.
Examples of Funded Projects
Not applicable.


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