Global AIDS


The U.S. President's Emergency Plan for AIDS Relief (PEPFAR) is the U.S. Government initiative to help save the lives of those suffering from HIV/AIDS around the world. This historic commitment is the largest by any nation to combat a single disease internationally, and PEPFAR investments also help alleviate suffering from other diseases across the global health spectrum. PEPFAR is the cornerstone and largest component of the U.S. President?s Global Health Initiative. With a special focus on improving the health of women, newborns and children, the Global Health Initiative?s goal is to save the greatest number of lives by increasing and building upon what works and, then, supporting countries as they work to improve the health of their own people.

General information about this opportunity
Last Known Status
Program Number
Federal Agency/Office
Centers For Disease Control and Prevention, Department of Health and Human Services
Type(s) of Assistance Offered
B - Project Grants
Program Accomplishments
Not applicable.
Sections 307 and 317(k)(2), Public Health Service Act, 42 U.S.C. 242I and 247b(k)(2) as amended; Public Law 108-25, the United States Leadership Against HIV/AIDS, Tuberculosis and Malaria Act of 2003 Public Law 110-293, the Tom Lantos and Henry J. Hyde United States Global Leadership Against HIV/AIDS, Tuberculosis, and Malaria Reauthorization Act of 2008, 22 U.S.C 7601; and Public Law 113-56 PEPFAR Stewardship and Oversight Act of 2013 (P.L. 113-56)., Public Law 108-25, 22 U.S.C. 7601
Who is eligible to apply/benefit from this assistance?
Applicant Eligibility
Competition is open, limited, or single eligibility by authorizing legislation.
Beneficiary Eligibility
This is only for non-research and research activities supported by CDC/ATSDR. For the definition of research, please see the CDC website at the following Internet address:
Requirements for application are stated in each Notice of Funding Opportunity
What is the process for applying and being award this assistance?
Pre-Application Procedure
Preapplication coordination is not applicable.
Application Procedure
2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. As specified in the Notice of Funding Opportunity
Award Procedure
As specified in the Notice of Funding Opportunity
Contact the headquarters or regional location, as appropriate for application deadlines
Approval/Disapproval Decision Time
As specified in the Notice of Funding Opportunity
Not applicable.
From 60 to 90 days. Renewals are made by competitive applications and Reviews.
How are proposals selected?
All applications will be initially reviewed for completeness by CDC Office of Grants Services (OGS) staff. Complete applications will be jointly reviewed for responsiveness by HHS/CDC Division of Global HIV and Tuberculosis and OGS Non-responsive applications will not advance to Phase II review. Applicants will be notified the application did not meet eligibility and/or published submission requirements. A review panel will evaluate complete, eligible applications in accordance with the criteria published in the Notice of Funding Opportunity. Applications will be funded in order by score and rank determined by the review panel unless funding preferences or other considerations stated in this NOFO apply. Final selection and approval of activities will be prioritized in collaboration with CDC.
How may assistance be used?
Uses and Restrictions are specified in individual Notice of Funding Opportunities. Funds may be spent for reasonable program purposes, including personnel, travel, operating costs including supplies, fuel for transportation, utilities, staff training costs including registration fees and purchase and rental of training related equipment, renovation of clinical or lab facilities; and purchase of HIV testing reagents, test kits and laboratory equipment for HIV testing and services. Equipment may be purchased if deemed necessary to accomplish program objectives; however, prior approval by CDC officials must be requested in writing. All requests for funds contained in the budget shall be stated in U.S. dollars. Once an award is made, CDC will not compensate foreign grantees for currency exchange fluctuations through the issuance of supplemental awards. The costs that are generally allowable in grants to domestic organizations are allowable to foreign institutions and international organizations, with the following exception: With the exception of the American University, Beirut, and the World Health Organization (WHO), Indirect Costs will not be paid (either directly or through sub-award) to organizations located outside the territorial limits of the United States or to international organizations regardless of their location. The applicant may contract with other organizations under this program; however the applicant must perform a substantial portion of the activities (including program management and operations, and delivery of prevention services for which funds are required). You must obtain an annual audit of these CDC funds (program-specific audit) by a U.S. - based audit firm with international branches and current licensure/authority in-country, and in accordance with International Accounting Standards or equivalent standard(s) approved in writing by CDC. A fiscal Recipient Capability Assessment may be required, prior to or post award, in order to review the applicant's business management and fiscal capabilities regarding the handling of U.S. Federal funds.
What are the requirements after being awarded this opportunity?
Performance Reports: As specified in the Notice of Funding Opportunity
Foreign recipients are subject to audit requirements specified in 45 CFR 74.26(d). A non-Federal audit is required, if during the recipients fiscal year, the recipient expended a total of $300,000.00 or more under one or more HHS awards (as a direct recipient and/or as a subrecipient) . The recipient either may have (1) A financial related audit (as defined in the Government Auditing Standards, GPO stock #020-000-00-265-4) of a particular award in accordance with Government Auditing Standards, in those case where the recipient receives awards under only one HHS program; or, if awards are received under multiple HHS programs, a financial related audit of all HHS awards in accordance with Government Auditing Standards; or (2) An audit that meets the requirements contained in OMB Circular A-133. Please forward a copy of the completed audit to the following address: Office of Grant Services, Centers for Disease Control and Prevention, Attn: Grants Management Officer, 2939 Flowers Road, Atlanta, GA 30341. If your audit was completed in accordance with number two (2) above, in addition to the address listed above, you are required to send a copy of the audit report to: Department of Health & Human Services, National External Audit Review Center Lucas Place, Room 514, 323 West 8th Street, Kansas City, MO 64105.
The Recipient Agreement Books and Records. The recipient must maintain accounting books, records, documents and other evidence relating to the Agreement, adequate to show, without limitation, all costs incurred by the recipient, the receipt and use of goods and services acquired by the recipient, agreed-upon cost sharing requirements, the nature and extent of solicitations of prospective suppliers of goods and services acquired by the recipient, the basis of award of recipient contracts and orders, and the overall progress of the Agreement toward completion ("Agreement books and records"). The recipient must maintain Agreement books and records in accordance with generally accepted accounting principles prevailing in the United States, or at the recipient's option, with approval by HHS/CDC, other accounting principles, such as those (1) prescribed by the International Accounting Standards Committee (an affiliate of the International Federation of Accountants), or (2) prevailing in the country of the recipient. Agreement books and records must be maintained for at least three years after the date of last disbursement by HHS/CDC or for such longer period, if any, required to resolve any litigation, claims or audit findings.
Other Assistance Considerations
Formula and Matching Requirements
Statutory formula is not applicable to this assistance listing.

Matching requirements are not applicable to this assistance listing.

MOE requirements are not applicable to this assistance listing.
Length and Time Phasing of Assistance
From one to five years. Throughout the project period, CDC's commitment to continuation of awards will be conditioned on the availability of funds, evidence of satisfactory progress by the recipient (as documented in required reports), and the determination that continued funding is in the best interest of the Federal Government. Method of awarding/releasing assistance: Lump.
Who do I contact about this opportunity?
Regional or Local Office
Tracey Moore, Branch Chief, Global Health Services Branch, (770)488-2074, 2939 Flowers Road, Atlanta, GA 30341.
Headquarters Office
Randi Daniels
1600 Clifton Road, NE, Mailstop H21-9
Atlanta, GA 30333 US
Phone: 404-718-6503
Website Address
Financial Information
Account Identification
(Cooperative Agreements) FY 18$1,083,607,334.00; FY 19 est $1,752,885,349.00; FY 20 est $1,600,000,000.00; FY 17$1,511,170,959.00; FY 16$2,354,719,081.00; -
Range and Average of Financial Assistance
$25,000 to $48,000,000. Average $2,700,000
Regulations, Guidelines and Literature
45 CFR Part 74 and Part 92 For more information on the Code of Federal Regulations, see the National Archives and Records Administration at the following Internet address:
Examples of Funded Projects
Not applicable.


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