Global AIDS


The U.S. President's Emergency Plan for AIDS Relief (PEPFAR) is the U.S. Government initiative to help save the lives of those suffering from HIV/AIDS around the world. This historic commitment is the largest by any nation to combat a single disease internationally, and PEPFAR investments also help alleviate suffering from other diseases across the global health spectrum. PEPFAR is the cornerstone and largest component of the U.S. Presidents Global Health Initiative. With a special focus on improving the health of women, newborns and children, the Global Health Initiatives goal is to save the greatest number of lives by increasing and building upon what works and, then, supporting countries as they work to improve the health of their own people.

General information about this opportunity
Last Known Status
Program Number
Federal Agency/Office
Centers For Disease Control and Prevention, Department of Health and Human Services
Type(s) of Assistance Offered
B - Project Grants
Program Accomplishments
Not applicable.
Sections 307 and 317(k)(2), Public Health Service Act, 42 U.S.C. 242I and 247b(k)(2) as amended; Public Law 108-25, the United States Leadership Against HIV/AIDS, Tuberculosis and Malaria Act of 2003 Public Law 110-293, the Tom Lantos and Henry J. Hyde United States Global Leadership Against HIV/AIDS, Tuberculosis, and Malaria Reauthorization Act of 2008, 22 U.S.C 7601; and Public Law 113-56 PEPFAR Stewardship and Oversight Act of 2013 (P.L. 113-56)., Public Law 108-25, 22 U.S.C. 7601
42 USC 287b 31 USC 6305 42 CFR 63a
Who is eligible to apply/benefit from this assistance?
Applicant Eligibility
Competition is open, limited, or single eligibility by authorizing legislation.
Beneficiary Eligibility
This is only for non-research and research activities supported by CDC/ATSDR. For the definition of research, please see the CDC website at the following Internet address:
Requirements for application are stated in each Notice of Funding Opportunity.
What is the process for applying and being award this assistance?
Pre-Application Procedure
Preapplication coordination is not applicable.
Application Procedure
2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. As specified in the Notice of Funding Opportunity
Award Procedure
After review and approval, a Notice of Award (NoA) will be prepared and processed, along with appropriate notification to the public. Initial awards provide funds for the first budget period (usually 12 months) and the NoA will indicate support recommended for the remainder of the project period, allocation of Federal funds by budget categories, award requirements, and special conditions, if any.
Contact the headquarters or regional location, as appropriate for application deadlines
Approval/Disapproval Decision Time
As specified in the Notice of Funding Opportunity.
Not applicable.
From 60 to 90 days. Project period of performance is 1 to 5 years. After initial awards, and subject to availability of funds, projects may be continued non-competitively contingent upon satisfactory progress by the recipient (as documented in required reports) and the determination that continued funding is in the best interest of the Federal government.
How are proposals selected?
All applications will be initially reviewed for completeness by CDC Office of Grants Services (OGS) staff. Complete applications will be jointly reviewed for responsiveness by HHS/CDC Division of Global HIV and Tuberculosis and OGS. Non-responsive applications will not advance to Phase II review. Applicants will be notified if the application did not meet eligibility and/or published submission requirements. A review panel will evaluate complete, eligible applications in accordance with the criteria published in the Notice of Funding Opportunity. Applications will be funded in order by score and rank determined by the review panel unless funding preferences or other considerations stated in the NOFO.
How may assistance be used?
Uses and Restrictions are specified in individual Notice of Funding Opportunities. Funds may be spent for reasonable program purposes, including personnel, travel, operating costs including supplies, fuel for transportation, utilities, staff training costs including registration fees and purchase and rental of training related equipment, renovation of clinical or lab facilities; and purchase of HIV testing reagents, test kits and laboratory equipment for HIV testing and services. Equipment may be purchased if deemed necessary to accomplish program objectives; however, prior approval by CDC officials must be requested in writing. All requests for funds contained in the budget shall be stated in U.S. dollars. Once an award is made, CDC will not compensate foreign grantees for currency exchange fluctuations through the issuance of supplemental awards. The costs that are generally allowable in grants to domestic organizations are allowable to foreign institutions and international organizations, with the following exception: With the exception of the American University, Beirut, and the World Health Organization (WHO), Indirect Costs will not be paid (either directly or through sub-award) to organizations located outside the territorial limits of the United States or to international organizations regardless of their location. The applicant may contract with other organizations under this program; however the applicant must perform a substantial portion of the activities (including program management and operations, and delivery of prevention services for which funds are required). You must obtain an annual audit of these CDC funds (program-specific audit) by a U.S. - based audit firm with international branches and current licensure/authority in-country, and in accordance with International Accounting Standards or equivalent standard(s) approved in writing by CDC. A fiscal Recipient Capability Assessment may be required, prior to or post award, in order to review the applicant's business management and fiscal capabilities regarding the handling of U.S. Federal funds.
What are the requirements after being awarded this opportunity?
Performance Reports: Annual Federal Financial Reports (FFR) and performance/progress reports are required. Final FFRs and performance reports are required. Other reporting may be required and will be outlined in the NOFO or the Notice of Award.
Audit Requirement Foreign Organizations: An organization that expends $300,000 or more in a fiscal year on its federal awards must have a single or program-specific audit conducted for that year. The audit period is an organization's fiscal year. The auditor shall be a U.S.-based Certified Public Accountant firm, the foreign government's Supreme Audit Institution or equivalent, or an audit firm endorsed by the U.S. Agency for International Development's Office of Inspector General. The audit must be completed in English and in US dollars, and submitted within the earlier of 30 days after receipt of the auditor's report(s), or nine (9) months after the end of the audit period. The audit report must be sent to the Office of Financial Resources, Risk Management and Internal Control Unit's Audit Resolution Team (ART) at After receipt of the audit report, CDC will resolve findings by issuing Final Management Determination Letters.
In accordance with 2 CFR ?200, as codified in 45 CFR ?75, there is a 3-year record retention requirement; records shall be retained beyond the 3-year period if final audit has not been done or findings resolved. Property records must be retained in accordance with HHS Grants Policy Statement requirements.
Other Assistance Considerations
Formula and Matching Requirements
Statutory formula is not applicable to this assistance listing.

Matching requirements are not applicable to this assistance listing.

MOE requirements are not applicable to this assistance listing.
Length and Time Phasing of Assistance
From one to five years. Throughout the project period, CDC's commitment to continuation of awards will be conditioned on the availability of funds, evidence of satisfactory progress by the recipient (as documented in required reports), and the determination that continued funding is in the best interest of the Federal Government. Notice of Award.
Who do I contact about this opportunity?
Regional or Local Office
None/Not specified.
Headquarters Office
Yvette Valentine
1600 Clifton Rd
Atlanta, GA 30333 USA
Phone: 4046394469
Website Address
Financial Information
Account Identification
(Cooperative Agreements) FY 22$1,969,875,454.00; FY 23 est $1,665,000,000.00; FY 24 est $1,700,000,000.00; FY 21$1,591,885,109.00; FY 20$2,314,341,089.00; FY 19$1,733,557,585.00; FY 18$1,083,607,334.00; FY 17$1,511,170,959.00; FY 16$2,354,719,081.00; -
Range and Average of Financial Assistance
Range: $1,600,000,000 to $1,700,000,000. Average $5,134,640,117
Regulations, Guidelines and Literature
CDC financial assistance mechanisms are in accordance with 2 CFR ?200, as codified in 45 CFR ?75. Any specific information will be identified in the NOFO to which applications are submitted.
Examples of Funded Projects
Not applicable.


Related Federal Grants

Federal Grants Resources