Emerging Infections Sentinel Networks


In its 1994 monograph, Addressing Emerging Infectious Disease Threats A Prevention Strategy for the United States, the Centers for Disease Control and Prevention (CDC) called for the establishment of provider-based Emerging Infections Sentinel Networks (EISNs) to monitor and evaluate conditions that are not covered by health department surveillance and that are likely to be seen by specific kinds of health providers. There are currently three provider-based networks established through CDCs EISN cooperative agreement programs: 1) Surveillance network of infectious disease specialists, 2) Global surveillance network of travel medicine clinics, and 3) Emergency department-based network of academically affiliated emergency departments for research on emerging infectious diseases. The first two networks (infectious disease specialists and travel medicine clinics) are non-research programs, and the third network (academically affiliated EDs) is a research program. These networks contribute to surveillance for emerging infectious diseases, including drug resistant, foodborne and waterborne, and vaccine-preventable or potentially vaccine-preventable diseases, and enhance information exchange leading to early identification of and response to trends and outbreaks. Objectives for the provider-based sentinel networks include the following: - To support linked groups of participating individuals or organizations in monitoring a variety of infectious disease problems and enhancing communication and collaboration among network members and the public health community; - To serve as readily accessible mechanisms to address urgent public health infectious disease problems rapidly; and - To improve understanding of specific public health issues, including, but not limited to, international travel, and enhance preparedness to meet new infectious disease threats among domestic and globally mobile populations. Additional objectives for the "research" EISN include: - To focus studies on the most important issues to be addressed by participating hospital EDs and CDC; and - To estimate the community burden of diseases.

General information about this opportunity
Last Known Status
Program Number
Federal Agency/Office
Centers For Disease Control and Prevention, Department of Health and Human Services
Type(s) of Assistance Offered
B - Project Grants
Program Accomplishments
Not applicable.
Public Health Service Act Sections 301(a)[42 U.S.C.241(a)], 307 [42 U.S.C.242l], 317(k)(1)[42 U.S.C.247b(k)(1)], and 317(k)(2)[42 U.S.C.247b(k)(2)], as amended.
Who is eligible to apply/benefit from this assistance?
Applicant Eligibility
Eligibility for this program is open, however, only institutions/organizations that meet and can demonstrate the necessary qualifications described in the published NOFOs for this program should apply. Additional eligibility information is also described below: There are both research and non-research funding opportunities under this program. For the research opportunity, only organizations currently operating a nationwide provider-based sentinel network that link academically affiliated hospital emergency departments in monitoring a variety of infectious disease problems are eligible. For the non-research opportunity, only organizations currently operating provider-based sentinel networks that link groups of participating individuals or organizations organized around either infectious disease clinicians or travel medicine in monitoring a variety of infectious disease problems are eligible. Applicants should refer to the published NOFOs for more information regarding applicant eligibility.
Beneficiary Eligibility
- Health Professionals - Anyone/general public
Only organizations currently operating provider-based sentinel networks that link academically affiliated hospital emergency departments, or groups of participating individuals/organizations organized around either infectious disease clinicians or travel medicine, in monitoring a variety of infectious disease problems should submit an application. Applicants must provide documentation of the applicant's qualifications, standing, and relationships in representing a group of academically affiliated hospital emergency departments or providers in a sentinel network. Include letters of support from network members.
What is the process for applying and being award this assistance?
Pre-Application Procedure
Preapplication coordination is not applicable.
Application Procedure
2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. Detailed instructions regarding application procedures and requirements will be included in the published NOFO for this program.
Award Procedure
Applications that are complete and responsive will be evaluated for scientific and technical merit by an Objective Review Panel (for the non-research funding opportunity) or a Special Emphasis Panel (SEP) (for the research funding opportunity) in accordance with CDC review policies and procedures. CDC will not review incomplete and non-responsive applications. Complete and responsive applications will undergo the appropriate review process (Objective Review or SEP Review), receive a written critique and be scored according to the published review criteria. Any deviation from this process will be detailed in the published NOFO for this program. Successful applicants will receive a Notice of Award (NOA) from CDC. The NOA shall be the only binding, authorizing document between the recipient and CDC. The NOA will be signed by an authorized Grants Management Officer. Initial award provides funds for the first budget period (usually 12 months) and the NOA will indicate support recommended for the remainder of the project period, allocation of Federal funds by budget categories, and special conditions, if any. Once competing applicants have been selected for the first year of funding in the project period, those selected will be eligible to submit annual non-competitive continuation applications for each successive budget period of the project period.
Contact the headquarters or regional location, as appropriate for application deadlines
Approval/Disapproval Decision Time
From 90 to 120 days.
Not applicable.
From 60 to 90 days. Awards under this Program are typically issued for 1- to 5-year project periods. Renewals at the end of each project period are expected to be made available via publishing of a Renewal - Competing Continuation NOFO with a complete application and review/award process as described above. Annual renewals within an awarded multi-year project period are made via a non-competitive process and are subject to the availability of funding.
How are proposals selected?
Applications will be evaluated on the review criteria described in the Notice of Funding Opportunity Announcements (NOFOs). In general, the review and selection process of complete and responsive applications to the NOFO consists of determination of the scientific and technical merit by objective or peer review, availability of funds, and relevance of program priorities and the priorities of CDC.
How may assistance be used?
Recipients may only expend funds for reasonable program purposes, including personnel, travel, supplies, and services, such as contractual. More detailed information regarding use of funding for specific projects/activities will be included in the published NOFOs for this program.
What are the requirements after being awarded this opportunity?
Performance Reports: Annual Federal Financial Reports (FFR) and performance/progress reports are required. Final FFRs and performance reports are required. Other reporting may be required and will be outlined in the NOFO or the Notice of Award.
Not applicable.
In accordance with 2 CFR ?200, as codified in 45 CFR ?75, there is a 3-year record retention requirement; records shall be retained beyond the 3-year period if final audit has not been done or findings resolved. Property records must be retained in accordance with HHS Grants Policy Statement requirements.
Other Assistance Considerations
Formula and Matching Requirements
Statutory formula is not applicable to this assistance listing.

Matching requirements are not applicable to this assistance listing.

MOE requirements are not applicable to this assistance listing.
Length and Time Phasing of Assistance
Financial assistance is provided for a 12-month budget period with a period of performance of up to five years subject to the availability of funds and satisfactory progress of the recipient. Notice of Award
Who do I contact about this opportunity?
Regional or Local Office
None/Not specified.
Headquarters Office
Yarnell Martin
1600 Clifton Road
MS: C8-1
Atlanta, GA 30329 US
Phone: 4047188842
Website Address
Financial Information
Account Identification
(Cooperative Agreements) FY 22$15,806,522.00; FY 23 est $15,038,293.00; FY 24 est $15,038,293.00; FY 21$5,231,677.00; FY 20$5,797,784.00; FY 19$1,600,000.00; FY 18$1,839,926.00; FY 17$1,730,000.00; FY 16$1,753,468.00; -
Range and Average of Financial Assistance
Award Range: $250k-$5m Average Award: $500k
Regulations, Guidelines and Literature
Regulations governing this program are/will be published in the Notice of Funding Opportunity and identified on the notices of award. Regulations are also published under 45 CFR 75 and also on the HHS Grants Policy Statement.
Examples of Funded Projects
Not applicable.


Related Federal Grants

Federal Grants Resources