Cancer Biology Research


To provide fundamental information on the cause and nature of cancer in people, with the expectation that this will result in better methods of prevention, detection and diagnosis, and treatment of neoplastic diseases. Cancer Biology Research includes the following research programs: cancer cell biology; cancer immunology, hematology and etiology; DNA and chromosomal aberrations; tumor biology and metastasis; and structural biology and molecular applications.

General information about this opportunity
Last Known Status
Program Number
Federal Agency/Office
National Institutes of Health, Department of Health and Human Services
Type(s) of Assistance Offered
B - Project Grants
Program Accomplishments
Fiscal Year 2016 It is estimated that 1,387 total awards will be made in FY2016. In FY2016, 340 competing RPG awards were made, which were 11.3% of the applications received. In FY2016, 10 competing SBIT/STTR awards were made, which were 7.4% of the applications received.
Fiscal Year 2017 In FY2017, the estimated total awards to be made are 324.
Fiscal Year 2018 In FY2018, the estimated total awards to be made are 320.
Fiscal Year 2019 In FY2019, the actual total awards made were 371.
Fiscal Year 2020 In FY2020, the actual total awards made was 422.
Fiscal Year 2021 In FY2021, total awards made were 397.
Fiscal Year 2022 In FY2022, the actual total awards made were 383.
Fiscal Year 2023 In FY2023, the estimated total awards to be made are 1,833.
Fiscal Year 2024 In FY2024, the estimated total awards to be made are 1,959.
Public Health Service Act, Section 301, 410, and 411, Public Law 78-410, 42 U.S.C. 241, as amended; Public Law 100-607, 42 U.S.C. 285 and 285a; Small Business Research and Development Enhancement, Act of 1992, as amended, Public Law 102-564.
Who is eligible to apply/benefit from this assistance?
Applicant Eligibility
The awardee will be a university, college, hospital, public agency, nonprofit research institution or for-profit organization that submits an application and receives a grant for support of research by a named principal investigator. To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council.
Beneficiary Eligibility
Any nonprofit or for-profit organization, company, or institution engaged in biomedical research.
For-profit organizations' costs are determined in accordance with Subpart 31.2 of the Federal Acquisition Regulations. For other grantees, costs will be determined in accordance with HHS Regulations 45 CFR Part 75 See the website for more information on the electronic submission of grants.
What is the process for applying and being award this assistance?
Pre-Application Procedure
Preapplication coordination is not applicable.
Application Procedure
2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. The NIH is in the process of a transition to fully electronic grant submission through (see for details). Depending on the grant mechanism, either form PHS-398 (Rev. June 2009) or form SF424(R&R) (January 2010) is the standard form. Both can be obtained at The standard application forms, as furnished by PHS must be used for this program. The following is a website address for NIH electronic submission of grant application information:
Award Procedure
Grants and cooperative agreements are funded based on scientific merit, program relevance, and program balance and are made annually. The initial grant award provides funds for the first budget period (usually 12 months) and letter Notice of Award indicates support recommended for the remainder of the project period, allocation of Federal funds by budget categories and special conditions, if any.
August 5, 2018 April 5, 2017 December 5, 2016 All Grants including renewals and supplements: April 5, August 5, December 5. Cooperative Agreements and contracts are usually submitted in response to a Request for Applications (RFA) or a Request for Proposals (RFP). The receipt date is stipulated in the RFA or RFP. Note that for New Investigator and Early Stage Investigators applying for an R01 resubmission there are expedited review dates described in NOT-OD-11-057 (
Approval/Disapproval Decision Time
Regular Grants: Approximately 10 months.
A principal investigator may question the substantive or procedural aspects of the review of his/her application by communicating with the staff of the Institute. A description of the NIH Peer Review Appeal procedures is available on the NIH home page
Applications submitted for renewal are reviewed and selected for funding on a competitive basis.
How are proposals selected?
Not applicable.
How may assistance be used?
Grants and cooperative agreements may be made to eligible institutions for the support of cancer research projects. The grants and cooperative agreements may be used for personnel, consultant costs, equipment, supplies, travel, patient costs, animals, alterations and renovations, miscellaneous items, and Facilities and Administrative Costs (formerly known as indirect costs).
What are the requirements after being awarded this opportunity?
Not applicable.
In addition, grants and cooperative agreements are subject to inspection and audits by DHHS and other Federal government officials.
Expenditures and other financial records must be retained for 3 years from the day on which the grantee submits the last financial status report for the report period.
Other Assistance Considerations
Formula and Matching Requirements
Statutory formula is not applicable to this assistance listing.

Matching requirements are not applicable to this assistance listing.

MOE requirements are not applicable to this assistance listing.
Length and Time Phasing of Assistance
Grants and Cooperative Agreements: Average 3 to 5 years, and a maximum of 5 years. Renewals may be awarded for additional periods of up to 5 years based on competitive peer review. Funding is provided through Monthly Demand Payment System or an Electronic Transfer System. Method of awarding/releasing assistance: Letter.
Who do I contact about this opportunity?
Regional or Local Office
None/Not specified.
Headquarters Office
Shamala K. Srinivas
9609 Medical Center Drive
Seventh Floor, West Tower, 7W530, MSC 9750
Rockville, MD 20850 US
Phone: 240-276-6442
Fax: 240-276-7682
Website Address
Financial Information
Account Identification
(Project Grants (Cooperative Agreements)) FY 22$818,446,535.00; FY 23 est $902,587,062.00; FY 24 est $947,554,213.00; FY 21$775,177,999.00; FY 20$749,456,900.00; FY 19$630,704,532.00; FY 18$555,658,000.00; -
Range and Average of Financial Assistance
Range: $3,000 to $4,384,609 Average: $477,528
Regulations, Guidelines and Literature
42 CFR 52; 45 CFR 75; Grants will be available under the authority of and administered in accordance with the PHS Grants Policy Statement and Federal regulations at 42 CFR 52 and 42 U.S.C. 241; Omnibus Solicitation of the Public Health Service for Small Business Innovation Research (SBIR) Grant and Cooperative Agreement Applications. Omnibus Solicitation of the National Institutes of Health for Small Business Technology Transfer (STTR) Grant Applications.
Examples of Funded Projects
Not applicable.


Related Federal Grants

Federal Grants Resources