Biomedical Research and Research Training


The National Institute of General Medical Sciences (NIGMS) supports basic research that increases our understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention. NIGMS-funded scientists investigate how living systems work at a range of levels from molecules and cells to tissues and organs, in research organisms, humans, and populations. Additionally, to ensure the vitality and continued productivity of the research enterprise, NIGMS provides leadership in training the next generation of scientists, in enhancing the diversity of the scientific workforce, and in developing research capacity throughout the country.

General information about this opportunity
Last Known Status
Program Number
Federal Agency/Office
National Institutes of Health, Department of Health and Human Services
Type(s) of Assistance Offered
B - Project Grants
Program Accomplishments
Not applicable.
Section 301 and Title IV of the Public Health Service Act, as amended.
Who is eligible to apply/benefit from this assistance?
Applicant Eligibility
NIGMS trainees must be U.S. citizens, non-citizen nationals, or permanent residents.
Beneficiary Eligibility
Any nonprofit or for-profit organization, company or institution engaged in biomedical research.
Each applicant for research projects must present a research plan and furnish evidence that scientific competence, facilities, equipment, and supplies are appropriate to carry out the plan.
What is the process for applying and being award this assistance?
Pre-Application Procedure
Preapplication coordination is not applicable.
Application Procedure
2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. NIH announces availability of funds for grant programs by issuing funding opportunity announcements in the NIH Guide for Grants and Contracts ( and on ( Application packages must be downloaded from and the majority must be submitted through This program is subject to the provisions of 45 CFR, Part 92 for state and local governments and 45 CFR, Part 72 for other organizations, as appropriate.
Award Procedure
All accepted applications are reviewed for scientific merit by an appropriate initial review group and by a national advisory council. National Research Service Award (NRSA) applications for the support of individual fellows and other applications requesting less than $50,000 direct costs per year are not reviewed by the council. All approved applications compete for available funds on the basis of scientific merit and program emphasis.
Contact the headquarters or regional location, as appropriate for application deadlines
Approval/Disapproval Decision Time
Project Grants: about 9 months. NRSA: (institutional) 9-12 months, (individual) 6 months. Small Business Innovation Research (SBIR)/Small Business Technology Transfer Research (STTR): about 7-1/2 months.
A principal investigator may question the substantive or procedural aspects of the review of his/her application by communicating with the staff of the Institute. A description of the NIH Peer Review Appeal procedures is available on the NIH website at
Renewal grants are generally made prior to the expiration of any current award.
How are proposals selected?
For an overview of NIGMS grant application and review, including funding policy, see For more information about NIGMS, visit
How may assistance be used?
NIGMS is organized into divisions that support research, research training, and capacity building in a range of scientific fields. Major areas in which these units fund research are listed below their names: Division of Biophysics, Biomedical Technology, and Computational Biosciences Facilitates advances in basic biomedical research by supporting the development of biophysical and computational methods and tools for understanding basic biological questions; physical and theoretical methodologies, bioinformatics tools, and sophisticated quantitative approaches to lay a foundation for advances in disease diagnosis, treatment, and prevention in health and disease; and the creation of innovative tools and new technologies for the study of macromolecular, cellular, and organelle processes and function. The long-term goals of the division are to leverage data, methods, and technologies to answer fundamental biological questions, to develop a more robust computing infrastructure for the biomedical research community, and to promote and facilitate the development and use of new biophysical, computational, and experimental technologies in biomedical research. Division of Genetics and Molecular, Cellular, and Developmental Biology Supports research to understand the structure and function of cells and cellular components, and the cellular and molecular mechanisms that underlie inheritance, gene expression, and development. In most cases, research whose overall goal is to gain knowledge about a specific organ or organ system or the pathophysiology, treatment, or cure of a specific disease or condition is not supported by this division. Division of Pharmacology, Physiology, and Biological Chemistry Supports a broad spectrum of research aimed at improving the molecular-level understanding of fundamental biological processes and discovering approaches to their control. Research supported by the division takes a multifaceted approach to problems in pharmacology, physiology, biochemistry, and biological chemistry that are very basic in nature. The goals of supported research include an improved understanding of drug action and of anesthesia; mechanisms underlying responses to drugs; new methods and targets for drug discovery; advances in natural products synthesis; an enhanced understanding of biological catalysis; knowledge of metabolic regulation and fundamental physiological processes; and the integration and application of basic physiological, pharmacological, and biochemical research to clinical issues in anesthesia, clinical pharmacology, and trauma and burn injury. Research approaches are state-of-the-art and employ the optimal research organisms for the problems being addressed. Division for Research Capacity Building Supports research, research training, faculty development, and research infrastructure improvements in states that historically have not received significant levels of research funding from NIH. It also supports faculty research development at institutions that have a historical mission focused on serving students from underrepresented groups, research and research capacity building directed by Native American and Alaska Native tribal organizations, and conducts a science education program designed to improve life-science literacy. Division of Training, Workforce Development, and Diversity Supports programs that foster research training and the development of a strong and diverse biomedical research workforce. The division funds research training, student development and career development activities through a variety of programs. In addition, it supports the NIH Common Fund initiative, Enhancing the Diversity of the NIH-Funded Workforce.
What are the requirements after being awarded this opportunity?
Performance Reports: Varies by program, always on an annual basis
Audits of profit making organizations are addressed in 45 CFR Part 72 (Subpart C, Section 74.26). In addition, grants and cooperative agreements are subject to inspection and audits by DHHS and other federal government officials.
Expenditures and other financial records must be retained for 3 years from the day on which the grantee submits the last financial status report for the report period.
Other Assistance Considerations
Formula and Matching Requirements
Statutory formula is not applicable to this assistance listing.

Matching requirements are not applicable to this assistance listing.

MOE requirements are not applicable to this assistance listing.
Length and Time Phasing of Assistance
Almost all awards are made for at least 1 year, with additional support (up to 4 more years) depending on the recommendation of the scientific review group, the national advisory council, successful annual performance and availability of funds. varies by program, always on an annual basis
Who do I contact about this opportunity?
Regional or Local Office
None/Not specified.
Headquarters Office
Susan Athey
45 Center Drive MSC6200
Bethesda, MD 20892 US
Phone: (301) 496-7301
Fax: (301) 402-0224
Website Address
Financial Information
Account Identification
(Project Grants) FY 18$2,675,446,000.00; FY 19 est $2,763,693,000.00; FY 20 est $2,375,898,000.00; FY 17$2,541,941,161.00; FY 16$2,411,311,000.00; -
Range and Average of Financial Assistance
$20,000 to $10,000,000.
Regulations, Guidelines and Literature
45 CFR 16 Procedures of the Departmental Grant Appeals Board; 45 CFR 74; 45 CFR 92; NIH Extramural Programs brochure; miscellaneous program literature from headquarters office. Grants will be available under the authority of and administered in accordance with the NIH Grants Policy Statement and federal regulations at 42 CFR 52 and 42 USC 241; Omnibus Solicitation of the Public Health Service for Small Business Innovation Research (SBIR) Grant and Cooperative Agreement Applications; and Omnibus Solicitation of the National Institutes of Health for Small Business Technology Transfer (STTR) Grant Applications.


Federal Grants Resources