Biomedical Research and Research Training


The National Institute of General Medical Sciences (NIGMS) supports basic research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment and prevention. NIGMS-funded scientists investigate how living systems work at a range of levels, from molecules and cells to tissues, whole organisms and populations. The Institute also supports research in certain clinical areas, primarily those that affect multiple organ systems. To assure the vitality and continued productivity of the research enterprise, NIGMS provides leadership in training the next generation of scientists, in enhancing the diversity of the scientific workforce, and in developing research capacities throughout the country.

General information about this opportunity
Last Known Status
Program Number
Federal Agency/Office
Agency: Department of Health and Human Services
Office: National Institutes of Health
Type(s) of Assistance Offered
Program Accomplishments
Not Applicable.
Section 301 and Title IV of the Public Health Service Act, as amended.
Who is eligible to apply/benefit from this assistance?
Applicant Eligibility
NIGMS trainees must be U.S. citizens, non-citizen nationals or permanent residents.
Beneficiary Eligibility
Any nonprofit or for-profit organization, company or institution engaged in biomedical research.
Each applicant for research projects must present a research plan and furnish evidence that scientific competence, facilities, equipment and supplies are appropriate to carry out the plan. 2 CFR 200, Subpart E - Cost Principles applies to this program.
What is the process for applying and being award this assistance?
Pre-Application Procedure
Preapplication coordination is not applicable. Environmental impact information is not required for this program. This program is excluded from coverage under E.O. 12372.
Application Procedure
This program is excluded from coverage under 2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards. NIH announces availability of funds for grant programs by issuing funding opportunity announcements in the NIH Guide for Grants and Contracts ( and on ( Application packages must be downloaded from and the majority must be submitted through This program is subject to the provisions of 45 CFR, Part 92 for state and local governments and 45 CFR, Part 72 for other organizations, as appropriate.
Award Procedure
All accepted applications are reviewed for scientific merit by an appropriate initial review group and by a national advisory council. National Research Service Award (NRSA) applications for the support of individual fellows and other applications requesting less than $50,000 direct costs per year are not reviewed by the council. All approved applications compete for available funds on the basis of scientific merit and program emphasis.
Contact the headquarters or regional office, as appropriate, for application deadlines.
Approval/Disapproval Decision Time
Project Grants: about 9 months. NRSA: (institutional) 9-12 months, (individual) 6 months. Small Business Innovation Research (SBIR)/Small Business Technology Transfer Research (STTR): about 7-1/2 months.
A principal investigator may question the substantive or procedural aspects of the review of his/her application by communicating with the staff of the Institute. A description of the NIH Peer Review Appeal procedures is available on the NIH Web site at
Renewal grants are generally made prior to the expiration of any current award.
How are proposals selected?
For an overview of NIGMS grant application and review, including funding policy, see For more information about NIGMS, visit
How may assistance be used?
NIGMS is organized into divisions and a center that support research and research training in a range of scientific fields. Major areas in which these units fund research are listed below their names:

Division of Biomedical Technology, Bioinformatics, and Computational Biology
Biomedical technology and software development
Cell and molecular modeling and simulation
Computational genomics
Database design and enhancement
High-throughput data analysis
Systems biology

Division of Cell Biology and Biophysics
Analytical and separation techniques
Biophysical properties of proteins and nucleic acids
Cell organization, motility and division
Cellular imaging
Membrane structure and function
Molecular biophysics
Single-molecule biophysics and nanoscience
Spectroscopic techniques
Structural biology
Structural genomics and proteomics

Division of Genetics and Developmental Biology
Chromosome organization and mechanics
Developmental biology and genetics
DNA replication, recombination and repair
Genetic basis of human biology
Neurogenetics and the genetics of behavior
Population genetics, evolution and the genetics of complex traits
Protein synthesis
Regulation of cell growth, cell division, cell death and differentiation
Regulation of cellular processes by signaling
RNA transcription and processing
Stem cell biology

Division of Pharmacology, Physiology, and Biological Chemistry
Bioenergetics and mitochondrial physiology
Biotechnology and metabolic engineering
Chemical biology and bio-inorganic chemistry
Drug absorption, distribution, metabolism, excretion and predictive toxicology
Glycomics and glycosciences
Molecular immunobiology
Pharmacology and clinical pharmacology
Synthetic chemistry
Trauma, burn injury and wound healing

Division of Training, Workforce Development, and Diversity
Undergraduate student training and development
Postbaccalaureate research education
Predoctoral research training
Postdoctoral research training, career development and transition to independence
Workforce development research

Center for Research Capacity Building
Undergraduate research experiences and student development
Junior faculty research development and mentoring
Basic, clinical and translational biomedical research, including on conditions that disproportionately affect medically underserved populations
The formation of collaborative research and training networks
The enhancement of biomedical research infrastructure and of access to shared research resources.
What are the requirements after being awarded this opportunity?
varies by program, always on an annual basis. varies by program, always on an annual basis. varies by program, always on an annual basis. varies by program, always on an annual basis. varies by program, always on an annual basis.
In accordance with the provisions of 2 CFR 200, Subpart F - Audit Requirements, non-Federal entities that expend financial assistance of $750,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Non-Federal entities that expend less than $750,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in 2 CFR 200.503. Audits of profit making organizations are addressed in 45 CFR Part 72 (Subpart C, Section 74.26). In addition, grants and cooperative agreements are subject to inspection and audits by DHHS and other Federal government officials.
Expenditures and other financial records must be retained for 3 years from the day on which the grantee submits the last financial status report for the report period.
Other Assistance Considerations
Formula and Matching Requirements
This program has no statutory formula.
Matching requirements are not applicable to this program.
MOE requirements are not applicable to this program.
Length and Time Phasing of Assistance
Almost all awards are made for at least 1 year, with additional support (up to 4 more years) depending on the recommendation of the scientific review group, the national advisory council, successful annual performance and availability of funds. See the following for information on how assistance is awarded/released: varies by program, always on an annual basis.
Who do I contact about this opportunity?
Regional or Local Office
Headquarters Office
Susan J. Athey 45 Center Drive MSC6200, Bethesda, Maryland 20892 Email: Phone: (301) 496-7301 Fax: (301) 402-0224
Website Address
Financial Information
Account Identification
(Project Grants) FY 14 $2,262,193,344; FY 15 est $2,206,688,000; and FY 16 est $2,328,114,000
Range and Average of Financial Assistance
$20,000 to $10,000,000.
Regulations, Guidelines and Literature
45 CFR 16 Procedures of the Departmental Grant Appeals Board; 45 CFR 74; 45 CFR 92; NIH Extramural Programs brochure; miscellaneous program literature from Headquarters Office. Grants will be available under the authority of and administered in accordance with the NIH Grants Policy Statement and Federal regulations at 42 CFR 52 and 42 USC 241; Omnibus Solicitation of the Public Health Service for Small Business Innovation Research (SBIR) Grant and Cooperative Agreement Applications. Omnibus Solicitation of the National Institutes of Health for Small Business Technology Transfer (STTR) Grant Applications.
Examples of Funded Projects
Fiscal Year 2014: No Current Data Available Fiscal Year 2015: No Current Data Available Fiscal Year 2016: No Current Data Available


Federal Grants Resources