21st Century Cures Act: Regenerative Medicine Initiative


To provide support for initiatives funded under the 21st Century Cures Act to support the BRAIN Initiatives aim of revolutionizing our understanding of the human brain. By accelerating the development and application of innovative technologies, researchers will be able to produce a revolutionary new dynamic picture of the brain that, for the first time, shows how individual cells and complex neural circuits interact in both time and space. Long desired by researchers seeking new ways to treat, cure, and even prevent brain disorders, this picture will fill major gaps in our current knowledge and provide unprecedented opportunities for exploring exactly how the brain enables the human body to record, process, utilize,

General information about this opportunity
Last Known Status
Program Number
Federal Agency/Office
National Institutes of Health, Department of Health and Human Services
Type(s) of Assistance Offered
B - Project Grants
Program Accomplishments
Not applicable.
21st Century Cures Act , Apprporiation75X5628
Small Business Research and Development Enhancement Act of 1992, Public Law 102-564
Who is eligible to apply/benefit from this assistance?
Applicant Eligibility
The awardee will be a university, college, hospital, public agency, nonprofit research institution or for-profit organization that applies and receives a grant for support of research by a named principal investigator. To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council.
Beneficiary Eligibility
Any nonprofit or for-profit organization, company, or institution engaged in biomedical research.
Applications must be submitted in compliance with instructions provided with each initiative.
What is the process for applying and being award this assistance?
Pre-Application Procedure
Preapplication coordination is not applicable.
Application Procedure
This program is excluded from coverage under 2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards.
Award Procedure
Grants and cooperative agreements are funded based on scientific merit, program relevance, and program balance and are made annually. The initial grant award provides funds for the first budget period (usually 12 months) and letter Notice of Award indicates support recommended for the remainder of the project period, allocation of Federal funds by budget categories and special conditions, if any.
Not applicable.
Approval/Disapproval Decision Time
Regular Grants: Approximately 10 months
A principal investigator may question the substantive or procedural aspects of the review of his/her application by communicating with the staff of the Institute. A description of the NIH Peer Review Appeal procedures is available on the NIH home page www.nih.gov/grants/guide/notice-files/not97-232.html .
Applications submitted for renewal are reviewed and selected for funding on a competitive basis.
How are proposals selected?
Not applicable.
How may assistance be used?
Grants and cooperative agreements may be made to eligible institutions for the support of the BRAIN Initiative. The grants and cooperative agreements may be used for personnel, consultant costs, equipment, supplies, travel, patient costs, animals, alterations and renovations, miscellaneous items, and Facilities and Administrative Costs (formerly known as indirect costs).
What are the requirements after being awarded this opportunity?
Not applicable.
Not applicable.
Expenditures and other financial records, and also administrative records, must be retained for 3 years from the day on which the grantee submits the last expenditure report for the grant period.
Other Assistance Considerations
Formula and Matching Requirements
Statutory formula is not applicable to this assistance listing.

Matching requirements are not applicable to this assistance listing.

MOE requirements are not applicable to this assistance listing.
Length and Time Phasing of Assistance
Grants and Cooperative Agreements: Average 3 to 5 years, and a maximum of 5 years. Renewals may be awarded for additional periods of up to 5 years based on competitive peer review. Method of awarding/releasing assistance: Letter.
Who do I contact about this opportunity?
Regional or Local Office
45 CFR 75, NIH Grants Policy Statement, SF 424
Headquarters Office
Dana A. Phares
National Institutes of Health
6701 Rockledge Drive, Room 7176
Bethesda, MD 20832 US
Phone: 301 827-7968
Financial Information
Account Identification
(Project Grants (Cooperative Agreements)) FY 22$2,045,429.00; FY 23 est $5,175,828.00; FY 24 est $4,774,391.00; FY 21$2,577,076.00; FY 20$3,097,550.00; FY 19$3,962,823.00; FY 18$0.00; FY 17$2,000,000.00; FY 16$0.00; -
Range and Average of Financial Assistance
Not applicable/available.
Regulations, Guidelines and Literature
45 CFR 75, NIH Grants Policy Statement, SF 424
Examples of Funded Projects
Not applicable.


Federal Grants Resources