21st Century Cures Act - Beau Biden Cancer Moonshot


To provide support for initiatives funded under the 21st Century Cures Act to support cancer research, such as the development of cancer vaccines, the development of more sensitive diagnostic tests for cancer, immunotherapy and the development of combination therapies, and research that has the potential to transform the scientific field, that has inherently higher risk, and that seeks to address major challenges related to cancer.

General information about this opportunity
Last Known Status
Program Number
Federal Agency/Office
National Institutes of Health, Department of Health and Human Services
Type(s) of Assistance Offered
B - Project Grants
Program Accomplishments
Fiscal Year 2017 FY2017 actual total awards to be made is 48.
Fiscal Year 2018 FY2018 actual total awards to be made is 28.
Fiscal Year 2019 FY2019 actual total awards made is 18.
Fiscal Year 2020 FY2020 actual awards made was 21.
Fiscal Year 2021 FY2021 total awards made was 9.
Fiscal Year 2022 FY2022 actual awards made were 16.
Fiscal Year 2023 FY2023 estimated total awards to be made is 125.
Fiscal Year 2024 FY2024 estimated total awards to be made is 0.
Act: Public Health Service Act, Sections 301, 410 and 412, Public Law 78-410, as amended, Public Law 99-500, Public Law 100-607, 42 U.S.C. 241, 42 U.S.C. 285 - 285a-1; Small Business Research and Development Enhancement Act of 1992, Public Law 102-564.
Who is eligible to apply/benefit from this assistance?
Applicant Eligibility
The awardee will be a university, college, hospital, public agency, nonprofit research institution or for-profit organization that applies and receives a grant for support of research by a named principal investigator. To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council.
Beneficiary Eligibility
Any nonprofit or for-profit organization, company, or institution engaged in biomedical research.
Applications must be submitted in compliance with instructions provided with each initiative.
What is the process for applying and being award this assistance?
Pre-Application Procedure
Preapplication coordination is not applicable.
Application Procedure
This program is excluded from coverage under 2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards.
Award Procedure
Grants and cooperative agreements are funded based on scientific merit, program relevance, and program balance and are made annually. The initial grant award provides funds for the first budget period (usually 12 months) and letter Notice of Award indicates support recommended for the remainder of the project period, allocation of Federal funds by budget categories and special conditions, if any.
Not applicable.
Approval/Disapproval Decision Time
Regular Grants: Approximately 10 months
From 15 to 30 days. A principal investigator may question the substantive or procedural aspects of the review of his/her application by communicating with the staff of the Institute. A description of the NIH Peer Review Appeal procedures is available on the NIH home page www.nih.gov/grants/guide/notice-files/not97-232.html .
From 30 to 60 days. Applications submitted for renewal are reviewed and selected for funding on a competitive basis.
How are proposals selected?
Funding decisions are based on scientific merit (42 CFR 52h) and program relevance. Scientific merit review encompasses: the peer review criteria detailed in the specific funding announcement, as well as the significance, approach, and innovation of the proposed research; the competency of the principal investigator; the adequacy of the resources and environment; the proposed budget and requested period of support; and, where applicable, the adequacy of the measures for protecting against adverse effects upon humans, animals, or the environment.
How may assistance be used?
Grants and cooperative agreements may be made to eligible institutions for the support of cancer research projects. The grants and cooperative agreements may be used for personnel, consultant costs, equipment, supplies, travel, patient costs, animals, alterations and renovations, miscellaneous items, and Facilities and Administrative Costs (formerly known as indirect costs).
What are the requirements after being awarded this opportunity?
Not applicable.
Expenditures and other financial records, and also administrative records, must be retained for 3 years from the day on which the grantee submits the last expenditure report for the grant period.
Expenditures and other financial records, and also administrative records, must be retained for 3 years from the day on which the grantee submits the last expenditure report for the grant period.
Other Assistance Considerations
Formula and Matching Requirements
Statutory formula is not applicable to this assistance listing.

Matching requirements are not applicable to this assistance listing.

MOE requirements are not applicable to this assistance listing.
Length and Time Phasing of Assistance
Grants and Cooperative Agreements: Average 3 to 5 years, and a maximum of 5 years. Renewals may be awarded for additional periods of up to 5 years based on competitive peer review. Method of awarding/releasing assistance: Letter.
Who do I contact about this opportunity?
Regional or Local Office
Not applicable
Headquarters Office
Catherine M. Battistone
9609 Medical Center Drive, Suite 7W532
Rockville, MD 20850 US
Phone: 240-276-6443
Fax: 240-276-7682
Website Address
Financial Information
Account Identification
(Cooperative Agreements) FY 22$49,889,327.00; FY 23 est $78,925,810.00; FY 24 est $0.00; FY 21$66,987,994.00; FY 20$59,946,333.00; FY 19$96,238,319.00; FY 18$86,243,000.00; FY 17$58,437,000.00; -
Range and Average of Financial Assistance
Range: $315,874 to $4,012,287 Average $1,153,339
Regulations, Guidelines and Literature
45 CFR 75, NIH Grants Policy Statement, SF 424
Examples of Funded Projects
Not applicable.


Federal Grants Resources