Oral Diseases and Disorders Research

 

NIDCR extramural research provides research funds to support basic, translational, and clinical research in dental, oral, and craniofacial health and disease through grants, cooperative agreements, and contracts that support scientists working in institutions throughout the United States and internationally. Extramural programs plan, develop, and manage scientific priorities through portfolio analyses and consultation with stakeholders, encouraging the most promising discoveries and emerging technologies for rapid translation to clinical applications. The Integrative Biology and Infectious Diseases programs supports basic and translational research programs on oral microbiology; salivary biology and immunology; oral and salivary gland cancers; neuroscience of orofacial pain and temporomandibular disorders; mineralized tissue physiology; dental biomaterials; and tissue engineering and regenerative medicine. The branch aims to accelerate progress in basic and translational research in these areas, and further stimulate the discovery pipeline based on clinical needs. The Translational Genomics Research programs supports basic and translational research in genetics, genomics, developmental biology, and data science toward the goal of improving dental, oral, and craniofacial health. The focus is on deciphering the genetic, molecular, and cellular mechanisms underlying dental, oral, and craniofacial development and anomalies. The Behavioral and Social Sciences Research programs supports basic and applied research to promote oral health, to prevent oral diseases and related disabilities, and to improve management of craniofacial conditions, disorders, and injury. The program prioritizes mechanistic research that contributes to a cumulative science of behavior change, to maximize the rigor, relevance, and dissemination of efficacious behavior change interventions. The Clinical Research programs supports patient-oriented, population, and community based research aimed at improving the dental, oral, and craniofacial health of the nation. The Center focuses on a variety of diseases and conditions through clinical trials, epidemiologic studies, practice-based research, the HIV/AIDS and oral health program, and studies of oral health disparities and inequities in all areas of NIDCR programmatic interest. The program encourages investigations that have the potential to translate findings into evidence-based clinical applications. The Research Training and Career Development extramural programs span the career stages of scientists, supporting research training and career development for PhD and dual degree DDS/DMD-PhD students, postdoctoral scholars, and early career, midcareer, and established investigators. The programs manage support for fellowships, research training grants, career development and career transition awards, NIH loan repayment awards, and diversity supplements to support research experiences for high school students through investigators. NIDCR participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. The SBIR program is intended to increase private sector commercialization of innovations derived from Federal research and development; to increase small business participation in Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. The STTR program is intended to stimulate and foster scientific and technological innovation through cooperative research and development carried out between small business concerns and research institutions; to increase private sector commercialization of innovations derived from Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. Extramural programs are accountable for the efficient and effective use of taxpayer funds to support research on dental, oral, and craniofacial diseases and disorders and improving the oral health of all Americans. Extramural programs support research and research training to establish the foundation for scientific discoveries that include transparent and rigorous planning, priority setting, continuous and consistent reviews of progress, and focus on the development of a diverse, highly skilled, and nimble workforce that can rapidly respond to scientific breakthroughs and public health challenges. Extramural programs are accountable for the efficient and effective use of taxpayer funds to support research on dental, oral, and craniofacial diseases and employ evaluation domains, from needs assessment and strategic planning to implementation and process evaluation, performance measurement, and outcomes and impact analysis to evaluate strategic objectives

Active 93.121 National Institutes of Health, Department of Health and Human Services B - Project Grants Fiscal Year 2022 NRSA F Awards and FTTPs: 115 Total: $5,653,447 NRSA T Awards and FTTPs: 18 Awards / 123 FTTPs Total: 6,973,957 Total Research Grant: 788 Awards at $358,541,419 Public Health Service Act, Title IV, Section 301, Public Law -78-410 Research Project Grants: Scientists at universities, colleges, medical and dental schools, hospitals, laboratories, and other public or private nonprofit and for-profit institutions. NRSA and career development awards: (1) Nonprofit domestic organizations may apply for institutional awards. (2) Individual candidates or applicants must arrange sponsorship by a public or nonprofit private institution having staff and facilities appropriate to the proposed research training program. (3) All awardees must be citizens, or non-citizen nationals, of the United States or have been admitted to the United States for permanent residence, except for K99/R00, F99/K00, and T90/R90 grants. (4) To be eligible, postdoctoral NRSA and career development awardees must have a professional or scientific degree (M.D., Ph.D., D.D.S., D.V.M., Sc.D., D.Eng., or equivalent domestic or foreign degree). Institutional applicants must be able to provide the staff and facilities suitable for the proposed research training. SBIR and STTR grants: Can be awarded only to domestic small business concerns that meet the following criteria: 1) Is organized for profit, with a place of business located in the United States, which operates primarily within the United States or which makes a significant contribution to the United States economy through payment of taxes or use of American products, materials or labor; 2) Is in the legal form of an individual proprietorship, partnership, limited liability company, corporation, joint venture, association, trust or cooperative, except where the form is a joint venture, there must be less than 50 percent participation by foreign business entities in the joint venture; 3) Be a concern which is more than 50% directly owned and controlled by one or more individuals (who are citizens or permanent resident aliens of the United States), other business concerns (each of which is more than 50% directly owned and controlled by individuals who are citizens or permanent resident aliens of the United States), or any combination of these; no single venture capital operating company, hedge fund, or private equity firm may own more than 50% of the concern, 4) Has, including its affiliates, not more than 500 employees, and 5) meets the other regulatory requirements found in 13 C.F.R. Part 121. For STTR awards, the small business must "partner" with a research institution in a cooperative research and development project . In both Phase I and Phase II for both SBIR and STTR, the research must be performed in the U.S. and its possessions. To be eligible for funding, all grant applications must be evaluated for scientific merit and program relevance by a scientific peer review group and the National Advisory Dental and Craniofacial Research Council. Health professionals, graduate students, undergraduate students, health professional students, scientists, researchers, and any nonprofit or for-profit organization, company or institution engaged in biomedical research. Research Project Grants: Applications must include the specific aims (objectives) of the research, background and significance, research design and methods, investigator qualifications, innovation, approach/methodology, and environment/resources for the proposed project. NRSA and career development awards: (1) Individual Award Candidates: the applicant's academic record, research experience, citizenship, institutional sponsorship, proposed research area, and plan for training, must be included in the application. (2) Institutional Award Candidates: the application must include the objectives, methodology, and resources for the research training program, the research qualifications and experience of participating faculty in training students and fellows, and the criteria to be used in selecting individuals for support. Costs will be determined in accordance with OMB Circular No. A-87 for State and Local Governments. Costs for for-profit organizations are determined in accordance with the Federal Acquisition Regulations Subpart 31.2. For other than State and Local Government grantees, costs will be determined by Health and Human Services (HHS) Regulations 45 CFR, Part 74, Subpart Q. For SBIR and STTR grants, the applicant organization (small business) must present an idea in the research plan that has potential for commercialization and furnish evidence that scientific competence, experimental methods, facilities, equipment, and funds requested are appropriate to carry out the plan. Preapplication coordination is not applicable. 2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. Applications for Federal assistance must be submitted electronically through Grants.gov (http://www.grants.gov) using the SF424 Research and Related (R&R) forms and the SF424 (R&R) Application Guide (http://grants.nih.gov/grants/forms.htm). A registration process through Grants.gov is necessary before submission. Applicants are strongly encouraged to start the registration process at least four weeks prior to the applications submission date. All accepted grant applications competing for research project grants, career development awards, and NSRA awards are reviewed by two advisory groups. Primary review is conducted by an initial review group composed of extramural peer scientists, and secondary review by the National Advisory Dental and Craniofacial Research Council (NADCRC). Secondary review of NRSA fellowship applications is conducted by NIDCR staff rather than by the NADCRC. All accepted SBIR/STTR applications are evaluated for scientific and technical merit by an appropriate initial review group and by the NADCRC. All applications receiving a priority score compete for available SBIR/STTR set-aside funds on the basis of scientific and technical merit and commercial potential of the proposed research, program relevance, and program balance among the areas of research. Contact the headquarters or regional location, as appropriate for application deadlines More than 180 days. Research Project Grants, SBIR/STTR, and NSRA: From 6 to 9 months. From 90 to 120 days. A Principal Investigator (PI) may question the technical or procedural aspects of the review of his/her application by communicating with the program staff of the Institute. A description of the NIH Peer Review Appeal procedures is available on the NIH home page: http://grants.nih.gov/grants/peer_review_process.htm#Appeals and in the Notice: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-11-064.html. More than 180 days. Grants: Applications for approval beyond the approved project period must be submitted at least 6 to 9 months in advance of the termination date. NRSA: Institutional Awards may be made up to 5 years. No individual may receive NIH/NRSA support at the postdoctoral level for more than 3 years, and total support of more than 6 years, unless a specific waiver is requested and approved. The primary criteria for evaluating grant applications include assessment of: (1) the scientific merit, significance and overall impact of the proposed study and its objectives; (2) the competency of the proposed investigator(s) to successfully pursue the project; (3) the innovation and novelty of the concepts, approaches, or methodologies; (4) the technical adequacy of the experimental design and approach; (5) the adequacy of the available proposed facilities and resources; (6) the necessity of the budget components requested in relation to the proposed project; and (7) the relevance and importance to the posted institute program objectives. Also evaluated, where applicable, but not scored are: (1) protections for human subjects; (2) inclusion of women, minorities, and children; (3) vertebrate animal welfare; and (4) adequate protection of research personnel and/or the environment, biosafety, biocontainment and the security of select agents; (5) resource sharing plans; (6) authentication of key biological and/or chemical resources, (7) budget and period of support. In addition, the following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: the potential of the proposed research for commercial application. Phase II grant applications will reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific and technical merit of the proposed approach for achieving the Phase II objectives; (3) the technological innovation, originality, or societal importance of the proposed research; and (4) the potential of the proposed research for commercial application. NRSA individual fellowship applications will be evaluated for: (1) overall impact/merit; (2) suitability of the applicant; (3) qualifications of the sponsor(s)/collaborator(s); (4) scientific merit of the research training plan; (5) training potential; and (6) institutional environment and commitment to training. NRSA institutional training grants are assessed for: (1) overall impact; (2) merit of the training program and institutional environment; (3) the experience and success of the training program directors, PIs, and mentors; (4) the trainee recruitment plan and selection; and (5) the training record of the program and/or institution. Career Development applications will be evaluated for: (1) overall impact; (2) qualifications of the candidate; (3) the career plan and career goals/objectives of the candidate; (4) scientific merit of the research plan. (5) qualifications of the mentor(s), consultant(s) and collaborator(s); and (5) institutional environment and commitment to career development. Research Project Grants and Cooperative Agreements: provide funds for salaries, equipment, supplies, travel, and other expenses associated with scientific investigation in the dental, oral and craniofacial health sciences. They are awarded to universities, colleges, medical and dental schools, hospitals, and other nonprofit and for-profit institutions. Awards include investigator-initiated project grants, exploratory and developmental grants, small grants, center grants, conference grants, and career development awards. Individual and institutional dual degree (DDS or DMD/PhD) awards provide support for research career development in both clinical and basic science. National Research Service Awards (NRSAs) provide support for research training in specified biomedical areas, and can be made to institutions to enable them to accept individuals for research training. Individuals who receive NRSAs may be obligated upon termination of the award to comply with service and payback provisions. SBIR Phase I grants (duration of approximately 6 months) provide support to establish the technical merit and feasibility of a proposed research effort that may lead to a commercial product or process. Phase II grants support the continuation of the research initiated in Phase I to further develop the commercial products or process initiated in Phase I. Only Phase I awardees are eligible to receive Phase II support. STTR Phase I grants (duration of typically 1 year) support cooperative efforts between small businesses and research institutes to determine the scientific and technical merit, and commercial feasibility of a product or process with potential for commercial application. Phase II funding is based on the results of the research initiated in Phase I and the scientific and technical merit, and commercial potential of the Phase II application. Not applicable. In addition, grants and cooperative agreements are subject to inspection and audits by DHHS and other Federal officials. Expenditures and other financial records must be retained for 3 years from the day on which the grantee submits the last expenditure report for the report period. Statutory formula is not applicable to this assistance listing.

Matching requirements are not applicable to this assistance listing.

MOE requirements are not applicable to this assistance listing. Research Project Grants: Approval of a project includes a determination of support for the authorized project period (generally not to exceed 5 years). Awards to support the project are made on an annual basis. At the time of initial award, the grant provides funds for the conduct of the project during the first budget period (usually 12 months) and the Notice of Grant Award indicates the support recommended and expected to be made available for the remainder of the project beyond the approved project period, an application for renewal must be submitted in accordance with the deadline dates and instructions attached to the form. SBIR Phase I awards are generally for 6 months; Phase II awards normally are for 2 years. STTR Phase I awards are generally for 1 year; Phase II awards are for 2 years. None/Not specified. Dr. Lynn Mertens King
6701 Democracy Blvd.; MSC 4878
Bethesda, MD 20892 US
lynn.king@nih.gov
Phone: (301) 767-5538 http://www.nidcr.nih.gov 75-0873-0-1-550 (Project Grants) FY 22$313,886,247.00; FY 23 est $327,698,000.00; FY 24 est $326,278,000.00; FY 21$354,711,131.00; FY 20$359,574,366.00; FY 19$352,693,514.00; FY 18$332,520,941.00; FY 17$310,249,153.00; FY 16$292,486,346.00; - These are our extramural numbers, excluding R&D, NRSA TAP, SBIR TAP and SBIR Admin Fund.(Cooperative Agreements) FY 22$57,282,576.00; FY 23 est $60,525,000.00; FY 24 est $60,263,000.00; - FY2022: research project grants: range $6,414-$3,166,933, average $431,789; NRSA: range $2,500-$630,282, average $93,536; SBIR/STTR: range $39,732-$1,338,339, average $521,928; Career development: range $50,000-$249,000, average $138,508. FY2023: research project grants: range $10,355 - $3,198,621 average $463,374; NRSA: range $19,075 - $645,669, average $122,037; SBIR/STTR: range $55,000 - $1,265,448 average $752,195; Career development: range $18,661 - $283,536, average $137,314. Grants: 42 CFR 66; 45 CFR 74; NIDCR Grants and Funding website (http://www.nidcr.nih.gov/GrantsAndFunding/), NIH Grants website (http://grants.nih.gov/grants/oer.htm). Grants will be available under the authority of and administered in accordance with the PHS Grants Policy Statement and Federal regulations at 42 CFR 52 and 42 USC 241; Omnibus Solicitation of the Public Health Service for Small Business Innovation Research (SBIR) Grant and Cooperative Agreement Applications. Omnibus Solicitation of the National Institutes of Health for Small Business Technology Transfer (STTR) Grant Applications. Not applicable.